CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Interferon beta-1bWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (4)


Name (Synonyms) Correlation
drug687 Clofazimine Wiki 0.71
drug892 Dietary intake, body composition, lifestyle, and CVD risk factors Wiki 0.71
drug1784 Moxibustion plus Cupping Wiki 0.71
drug2443 Ribavirin Wiki 0.35

Correlated MeSH Terms (2)


Name (Synonyms) Correlation
D001835 Body Weight NIH 0.50
D003289 Convalescence NIH 0.32

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There are 2 clinical trials

Clinical Trials


1 An Open-label Randomised Controlled Trial on Dual Therapy With Interferon Beta-1b and Clofazimine Combination, as Treatment for COVID-19 Infection

To conduct an open-label randomized controlled trial on a short course of interferon β-1b and clofazimine combination treatment for patients hospitalized for COVID-19 infection. To assess its safety and clinical efficacy.

NCT04465695 COVID-19 Drug: Interferon beta-1b Drug: Clofazimine

Primary Outcomes

Description: Time to complete alleviation of symptoms as defined by NEWS of 0 maintained for 24 hours

Measure: Clinical alleviation of symptoms

Time: 7 days

Secondary Outcomes

Description: Length of hospitalisation

Measure: Hospitalisation

Time: 14 days

Description: Time to negative nasopharyngeal swab, throat saliva and sputum viral load by RT-PCR

Measure: Time to negative viral load

Time: 7 days

Description: Cytokine/ chemokine changes

Measure: Inflammatory changes

Time: 7 days

Description: One month mortality rate

Measure: Mortality

Time: 30 days

Description: Adverse events during and shortly after treatment

Measure: Adverse events

Time: 30 days

2 An Open-label Randomised Controlled Trial on IFN Beta-1b and Ribavirin Combination, as Treatment for Covid-19 Infection

As of 1 July 2020, more than 10 million people been confirmed to have infected by SARS-CoV-2, resulting in more than 500,000 deaths. No specific antiviral treatment for the SARS-CoV-2 is currently available, but existing medication could be repurposed. The investigators therefore propose to conduct an open-label randomized controlled trial on a short course of interferon β-1b and ribavirin combination treatment for patients hospitalized for COVID-19 infection.

NCT04494399 Covid19 Drug: Interferon beta-1b Drug: Ribavirin

Primary Outcomes

Description: Time to complete alleviation of symptoms as defined by NEWS2 of 0 maintained for 24 hours

Measure: Clinical symptoms alleviation

Time: 7 days

Secondary Outcomes

Description: Length of hospitalisation

Measure: Hospitalisation

Time: 14 days

Description: Time to negative nasopharyngeal swab and throat saliva viral load by RT-PCR

Measure: Time to negative viral load

Time: 7 days

Description: Cytokine/ chemokine changes

Measure: Inflammatory changes

Time: 7 days

Description: One month mortality rate

Measure: Mortality

Time: 30 days

Description: Adverse events and serious adverse events within 30 days of treatment

Measure: Adverse events and serious adverse events

Time: 30 days


No related HPO nodes (Using clinical trials)