Name (Synonyms) | Correlation | |
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drug3343 | mindfulness, emotion didactics, interpersonal skills, experiential learning Wiki | 1.00 |
drug96 | ARDSNet Wiki | 1.00 |
Name (Synonyms) | Correlation | |
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D013577 | Syndrome NIH | 0.10 |
D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.09 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.08 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.05 |
D018352 | Coronavirus Infections NIH | 0.04 |
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There is one clinical trial.
This is a prospective, randomized, single-center, open-label controlled trial, designed to compare the efficacy of two ventilation strategies (Low Tidal Volume and positive end-expiratory pressure (PEEP) based on the Acute Respiratory Distress Syndrome (ARDS) Network low PEEP-fraction of inspired oxygen inspired oxygen fraction (FIO2) Table versus Low Driving Pressure and PEEP guided by Electrical Impedance Tomography (EIT) in reducing daily lung injury score in patients with acute respiratory distress syndrome caused by COVID-19. The two strategies incorporate different prioritizations of clinical variables. The PEEP-FIO2 table strategy aims to reduce lung overdistension, even if it requires tolerating worse gas exchange. EIT-guided strategy prioritizes mechanical stress protection, avoiding alveolar overdistension and collapse.
Description: This score originally ranges from 0 to 4 points based on the average of 4 parameters (PaO2/FiO2, chest X-Ray, PEEP level, and Respiratory compliance). In the modified version, if the patient dies, he or she automatically receives a score of 5 irrespective of the other four parameters. If the patient is extubated, the score is automatically zero. We also substituted FiO2 for PEEP guaranteeing equivalence of the score when either the low or high PEEP-FiO2 table is applied.
Measure: Average daily Modified Lung injury score until day 28 Time: dailyDescription: Number of days with less than or equal to 1 Liter/min of oxygen supplementation until day 28
Measure: High oxygen dependence free days until day 28 Time: 28 daysDescription: Number of days free of mechanical ventilation assistance after protocol inclusion and before day 28
Measure: Mechanical ventilation free days until day 28 Time: 28 daysDescription: Occurrence of shock (persistent hypotension despite rescue measures) and incidence of barotrauma
Measure: Incidence of shock or barotrauma Time: 28 daysDescription: Occurrence of acute renal failure that justifies renal replacement therapy
Measure: Incidence of acute renal failure requiring renal replacement therapy Time: 28 daysDescription: Percentage of patients who died in each arm up to 28 days
Measure: 28-day mortality Time: 28 days