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CholecalciferolWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (4)


Name (Synonyms) Correlation
drug1675 MakAir Wiki 0.71
drug1004 Enoxaparin Wiki 0.20
drug1489 Ivermectin Wiki 0.16
drug313 Azithromycin Wiki 0.12

Correlated MeSH Terms (7)


Name (Synonyms) Correlation
D020141 Hemostatic Disorders NIH 0.19
D001778 Blood Coagulation Disorders NIH 0.19
D011024 Pneumonia, Viral NIH 0.09
D055371 Acute Lung Injury NIH 0.07
D012127 Respiratory Distress Syndrome, Newborn NIH 0.07
D012128 Respiratory Distress Syndrome, Adult NIH 0.06
D011014 Pneumonia NIH 0.04

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0001928 Abnormality of coagulation HPO 0.19
HP:0002090 Pneumonia HPO 0.04

There are 2 clinical trials

Clinical Trials


1 A Pilot Study for COVID-19 Outpatient Treatment With the Combination of Ivermectin-azithromycin-cholecalciferol

As the world faces COVID-19, the search for effective treatments against the disease and its complications has turned its gaze to drugs that are classically used in other infectious diseases. Some drugs are being examined for the recent evidence on its effects on viral replication and inflammation, one is Azithromycin, used to treat a wide variety of bacterial infections, Ivermectin, an anti-parasitic drug and the other is Cholecalciferol to increase serum concentration of 25-hydroxyvitamin D.

NCT04399746 COVID Drug: Ivermectin Drug: Azithromycin Drug: Cholecalciferol

Primary Outcomes

Description: Test for virus at day 1 and 14 from beginning of trial drug started

Measure: Viral clearance

Time: 14 days

Secondary Outcomes

Description: The duration of symptoms in days

Measure: Symptoms duration

Time: 14 days

Description: oxygen saturation

Measure: SpO2

Time: 14 days

Description: Oxygen Saturation (SpO2)/Fraction of Inspired Oxygen (FiO2) Ratio

Measure: SpO2/FiO2

Time: 14 days

2 Efficacy of Vitamin D Treatment in Pediatric Patients Hospitalized by COVID-19: Open Controlled Clinical Trial

Open controlled clinical trial. Hospitalized pediatric patients with COVID-19 will be included. Upon admission to hospital serum determination of vitamin D, interleukins, ferritin and Dimer D will be performed. Subsequently, randomization will be performed to identify which group the patient belongs. Adverse effects will be evaluated on a daily basis. Serum levels of interleukin (IL) -2, 6, 7,10, ferritin and dimer-D will be taken at the beginning of hospitalization and on the 7th day after admission. It will be recorded if the patient presents deterioration of the respiratory function that requires endotracheal intubation and / or admission to intensive care and / or if he dies, and at what time of hospitalization does this outcome occur. The study will culminate when the patient is discharged from hospitalization.

NCT04502667 Covid19 Vitamin D Children, Only Drug: Cholecalciferol

Primary Outcomes

Description: Taken on admission of the patient to hospitalization (through venipuncture measured by an in-vitro diagnostic enzyme immunoassay (ELISA) for quantitative determination) and on day 7 of hospitalization.

Measure: INTERLEUKINS (IL-2,6,7,10) (pg/ml)

Time: 7 days

Description: Taken on admission of the patient to hospitalization (through venipuncture measured by an in-vitro diagnostic enzyme immunoassay (ELISA) for quantitative determination) and on day 7 of hospitalization.

Measure: FERRITIN (ng/ml)

Time: 7 days

Description: Taken on admission of the patient to hospitalization (through venipuncture measured by an in-vitro diagnostic enzyme immunoassay (ELISA) for quantitative determination) and on day 7 of hospitalization.

Measure: DIMER-D

Time: 7 days

Secondary Outcomes

Description: determination of 25-hydroxy-Vitamin D in human serum

Measure: Vitamin D (ng/ml)

Time: the beginning and through study completion, an average of 21 days


No related HPO nodes (Using clinical trials)