Name (Synonyms) | Correlation | |
---|---|---|
drug1675 | MakAir Wiki | 0.71 |
drug1004 | Enoxaparin Wiki | 0.20 |
drug1489 | Ivermectin Wiki | 0.16 |
drug313 | Azithromycin Wiki | 0.12 |
Name (Synonyms) | Correlation | |
---|---|---|
D020141 | Hemostatic Disorders NIH | 0.19 |
D001778 | Blood Coagulation Disorders NIH | 0.19 |
D011024 | Pneumonia, Viral NIH | 0.09 |
D055371 | Acute Lung Injury NIH | 0.07 |
D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.07 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.06 |
D011014 | Pneumonia NIH | 0.04 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0001928 | Abnormality of coagulation HPO | 0.19 |
HP:0002090 | Pneumonia HPO | 0.04 |
There are 2 clinical trials
As the world faces COVID-19, the search for effective treatments against the disease and its complications has turned its gaze to drugs that are classically used in other infectious diseases. Some drugs are being examined for the recent evidence on its effects on viral replication and inflammation, one is Azithromycin, used to treat a wide variety of bacterial infections, Ivermectin, an anti-parasitic drug and the other is Cholecalciferol to increase serum concentration of 25-hydroxyvitamin D.
Description: Test for virus at day 1 and 14 from beginning of trial drug started
Measure: Viral clearance Time: 14 daysDescription: The duration of symptoms in days
Measure: Symptoms duration Time: 14 daysDescription: oxygen saturation
Measure: SpO2 Time: 14 daysDescription: Oxygen Saturation (SpO2)/Fraction of Inspired Oxygen (FiO2) Ratio
Measure: SpO2/FiO2 Time: 14 daysOpen controlled clinical trial. Hospitalized pediatric patients with COVID-19 will be included. Upon admission to hospital serum determination of vitamin D, interleukins, ferritin and Dimer D will be performed. Subsequently, randomization will be performed to identify which group the patient belongs. Adverse effects will be evaluated on a daily basis. Serum levels of interleukin (IL) -2, 6, 7,10, ferritin and dimer-D will be taken at the beginning of hospitalization and on the 7th day after admission. It will be recorded if the patient presents deterioration of the respiratory function that requires endotracheal intubation and / or admission to intensive care and / or if he dies, and at what time of hospitalization does this outcome occur. The study will culminate when the patient is discharged from hospitalization.
Description: Taken on admission of the patient to hospitalization (through venipuncture measured by an in-vitro diagnostic enzyme immunoassay (ELISA) for quantitative determination) and on day 7 of hospitalization.
Measure: INTERLEUKINS (IL-2,6,7,10) (pg/ml) Time: 7 daysDescription: Taken on admission of the patient to hospitalization (through venipuncture measured by an in-vitro diagnostic enzyme immunoassay (ELISA) for quantitative determination) and on day 7 of hospitalization.
Measure: FERRITIN (ng/ml) Time: 7 daysDescription: Taken on admission of the patient to hospitalization (through venipuncture measured by an in-vitro diagnostic enzyme immunoassay (ELISA) for quantitative determination) and on day 7 of hospitalization.
Measure: DIMER-D Time: 7 daysDescription: determination of 25-hydroxy-Vitamin D in human serum
Measure: Vitamin D (ng/ml) Time: the beginning and through study completion, an average of 21 days