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Taking blood samples for analyzing progesterone levelsWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation

Correlated Drug Terms (0)

Name (Synonyms) Correlation

Correlated MeSH Terms (5)

Name (Synonyms) Correlation
D013923 Thromboembolism NIH 0.27
D013927 Thrombosis NIH 0.22
D011014 Pneumonia NIH 0.06
D045169 Severe Acute Respiratory Syndrome NIH 0.05
D018352 Coronavirus Infections NIH 0.04

Correlated HPO Terms (2)

Name (Synonyms) Correlation
HP:0001907 Thromboembolism HPO 0.24
HP:0002090 Pneumonia HPO 0.06

There is one clinical trial.

Clinical Trials

1 The Effect of Early and Mid Luteal Blood Progesterone Levels on Ongoing Pregnancy Rates in IVF Cycles With Fresh Blastocyst Transfer

Progesterone (P4) is essential for the secretory development of endometrium and the maintenance of early pregnancy. In the luteal phase following controlled ovarian stimulation in in vitro fertilization (IVF) treatment, P4 profile is completely different from natural cycles (Fauser, 2002). Since the optimal luteal P4 levels are not well known, in normal IVF treatment a standard regime of exogenous P4 is given without considering the ovarian response for stimulation and the steroid levels in luteal phase. In 2005 Humaidan et al, showed that following the fresh embryo transfer, low luteal P4 levels (39 nmol/l) has a negative impact on ongoing pregnancy rates (Humaidan, 2005). In the following randomized controlled trials (RCTs), the use of exogenous human chorionic gonadotropin (hCG) after gonadotropin releasing hormone (GnRH) agonist trigger as a luteal phase support (Humaidan, 2010, 2013), the mid luteal P4 levels increased to 77-409 nmol/l and birth rates per transfer raised to %24. In the light of these, it is essential that the progesterone levels in luteal phase is above the certain threshold for induction of the normal secretory development of endometrium following the IVF treatment and for the maintenance of pregnancy. The implantation window is defined as that period when the uterus is receptive for implantation of the free-lying blastocyst. For maximal effectiveness of assisted reproductive technologies in women, it is important to know the optimal time for embryo transfer which implies a need to predict the period of uterine receptivity. Blood progesterone levels can be an indirect indication for implantation window and the embryo transfer timing. The aim of this study is to investigate the effect of early and mid luteal progesterone levels on ongoing pregnancy rates and to determine the optimal luteal P4 levels in IVF cycles following the fresh blastocyst transfer in order to improve the reproductive outcomes.

NCT04128436 Luteal Phase Progesterone Levels Other: Taking blood samples for analyzing progesterone levels

Primary Outcomes

Description: Clinically proven pregnancy more than 12 weeks of gestation

Measure: Ongoing pregnancy rates

Time: 12 months

Secondary Outcomes

Description: Concentration of blood progesterone on the day of OPU+2/3

Measure: Early luteal phase blood progesterone levels

Time: 12 months

Description: Concentration of blood progesterone on the day of OPU+5/ embryo transfer day

Measure: Mid luteal phase blood progesterone levels

Time: 12 months

No related HPO nodes (Using clinical trials)