Correlated Drug Terms (3)

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	Name (Synonyms)	Correlation
drug2722	Standard therapy for AUD plus Chess-based cognitive treatment Wiki	1.00
drug2724	Standard therapy for TUD Wiki	1.00
drug2721	Standard therapy for AUD Wiki	1.00

Correlated MeSH Terms (1)

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	Name (Synonyms)	Correlation
D019966	Substance-Related Disorders NIH	0.33

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: fMRI cue-reactivity task (Vollstädt-Klein et al. 2010)

Measure: change in neural cue-reactivity

Time: 2 time points: before and after 6 weeks chess-based cognitive training

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Description: fMRI sequential reinforcement-based task (Huys et al. 2012)

Measure: change in sequential reinforcement-based neural mechanisms

Time: 2 time points: before and after 6 weeks chess-based cognitive training

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Description: fMRI stop-signal task (Whelan et al. 2012)

Measure: change in neural correlates of inhibition

Time: 2 time points: before and after 6 weeks chess-based cognitive training

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Description: self-report

Measure: substance use (alcohol consumption and tabacco use)

Time: 3 months follow-up after the end of treatment

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Description: fMRI spatial working memory task (Vollstädt-Klein et al. 2010)

Measure: change in neural working memory processes

Time: 2 time points: before and after 6 weeks chess-based cognitive training

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Description: working memory capacity measured by letter-number sequencing task of the [Wechsler Memory Scale (Kent 2013)]; raw values will be transformed to IQ-like scales (mean 100, SD 15); the higher the value, the higher the working memory capacity

Measure: Change in working memory capacity

Time: 3 time points: before and after 6 weeks SCP plus after 3 months

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Description: One Touch Stockings of Cambridge task from the Cambridge Automated Neuropsychological Test Automated Battery (Robbins et al. 1994)

Measure: Change in planning ability

Time: 3 time points: before and after 6 weeks SCP plus after 3 months

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Description: Internal-External Set Shifting task from the Cambridge Automated Neuropsychological Test Automated Battery (Robbins et al. 1994)

Measure: Change in cognitive flexibility

Time: 3 time points: before and after 6 weeks SCP plus after 3 months

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Description: impulsivity measured with BIS scale [Barratt impulsiveness scale (Patton et al. 1995)];range 15-60; total score will be used; high values represent high impulsivity

Measure: Change in impulsivity

Time: 3 time points: before and after 6 weeks SCP plus after 3 months

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Description: [Iowa Gambling Task (Bechara et al. 1994)]

Measure: Change in decision-making

Time: 3 time points: before and after 6 weeks SCP plus after 3 months

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Description: [Reversal learning task (Vanes et al. 2014)]

Measure: Change in mental flexibility

Time: 3 time points: before and after 6 weeks SCP plus after 3 months

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Description: [d2 Test of Attention (Brickenkamp 2002)].

Measure: Change in attentional capacity

Time: 3 time points: before and after 6 weeks SCP plus after 3 months

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Secondary Outcomes

Description: [measured with fMRI]

Measure: change in functional connectivity within the salience network (SN) and executive control network (ECN)

Time: 2 time points: before and after 6 weeks therapy and chess-based cognitive training

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