CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Cospherunate/AzythromycineWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (2)


Name (Synonyms) Correlation
drug781 Cospherunate/Phytomedicine/Azythromycien Wiki 1.00
drug1333 Hydroxycloroquine and Azythromycine Wiki 1.00

Correlated MeSH Terms (2)


Name (Synonyms) Correlation
D006973 Hypertension NIH 0.26
D002318 Cardiovascular Diseases NIH 0.19

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0000822 Hypertension HPO 0.26
HP:0001626 Abnormality of the cardiovascular system HPO 0.19

There is one clinical trial.

Clinical Trials


1 Évaluationefficacité et tolérance d'Une médication à Base de Cosphérunate et d'un phytomédicament Antiviral Par Voie Orale en Comparaison Avec un Traitement à Base d'Hydroxychloroquine Chez Des Adultes Malades Covid-19 Sans Complications

The phase II clinical trial, with three arms and at rate of 10 patients per arm, received the approval of the National Committee for Ethics and Health Research. This is a non inferiority test aimed to compare the efficacy and safety in add on to Azithromycin, an antimalarial drug, a treatment combination of the antimalrial drug with an antiviral phytomedicine versus Hydroxychloroquine in COVID-19 patients without complications. During the treatment, viral clearance, adverse effects related to treatment, and symptoms progression will be assessed on days 3, 6 and 14. Clinical, paraclinical and laboratory tests will be performed throughout the 3-month trial. Ethical and deontological considerations will be applied.

NCT04502342 Covid19 Combination Product: Hydroxycloroquine and Azythromycine Combination Product: Cospherunate/Azythromycine Combination Product: Cospherunate/Phytomedicine/Azythromycien

Primary Outcomes

Description: Virological clearance from admission to discharge at days 3, 6 and 14

Measure: Virological clearance of throat swabs or lower respiratory tract secretions

Time: day 3 to day 14

Secondary Outcomes

Description: number of patients who developed treatment-related adverse effects

Measure: Adverse effects

Time: day 1 to day 14

Description: number of patients whose conditions worsened

Measure: Worsened conditions

Time: day 1 to day 14

Description: number of patients whose fever, cough and any other clinical sign observed on introduction have resolved

Measure: COVID-19 symptoms

Time: day 1 to day 14


No related HPO nodes (Using clinical trials)