CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


CannabidiolWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (2)


Name (Synonyms) Correlation
drug2055 Parents and Infants Engaged Wiki 0.71
drug2031 PLACEBO Wiki 0.50

Correlated MeSH Terms (5)


Name (Synonyms) Correlation
D065886 Neurodevelopmental Disorders NIH 0.50
D000067877 Autism Spectrum Disorder NIH 0.24
D040921 Stress Disorders, Traumatic NIH 0.14
D013313 Stress Disorders, Post-Traumatic NIH 0.13
D004194 Disease NIH 0.12

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0000729 Autistic behavior HPO 0.24

There are 2 clinical trials

Clinical Trials


1 Cannabidiol (CBD) in Patients With Mild to Moderate Symptoms of Coronavirus 2019: A Randomized, Double-blind, Placebo-controlled Clinical Trial

The aim of this work is to conduct a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of cannabidiol (CBD - 300 mg a day) in patients infected with SARS-CoV-2. The specific objectives are to assess whether, in patients with mild and moderate forms of SARS-CoV-2, daily use of CBD 300 mg for fourteen days is capable of: i) decrease viral load; ii) modify inflammatory parameters, such as cytokines, measured from serum; iii) reduce clinical and emotional symptoms through daily clinical evaluation; iv) improve sleep; v) reduce hospitalization and worsen the severity of the disease; v) Monitor the possible adverse effects of CBD use in these patients.

NCT04467918 SARS-CoV2 Drug: Cannabidiol Other: PLACEBO

Primary Outcomes

Description: Mean reduction in viral load (reduction of ≥1 log10) over time during the study period

Measure: Reduction in viral load

Time: Up to 28 days

Secondary Outcomes

Description: Clinical CoVid19 symptoms improvement

Measure: Number of participants with negative Clinical CoVid19 symptoms as assessed by CTCAE v5.0

Time: Up to 28 days

Description: Immune reaction

Measure: Change in proinflammatory cytokine concentration

Time: Up to 28 days

Description: A qualitative CT analysis of parenchymal lung damage induced by COVID-19

Measure: Describe the parenchymal lung damage induced by COVID-19 through a qualitative analysis with chest CT

Time: 14 days

Description: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]

Measure: Number of participants with treatment-related adverse events as assessed by CTCAE v5.0

Time: Up to 28 days

Description: Time to clinical improvement

Measure: Time to clinical improvement with CTCAE v5.0 CoVid19 symptoms to 0

Time: Up to 28 days

Description: CoVid severity worsening

Measure: Number of participants that need hospitalisation

Time: Up to 28 days

Description: Mortality

Measure: 28-day mortality

Time: Up to 28 days

Description: Time to negative saliva

Measure: Time to negative saliva 2019-n-CoV RT-PCR

Time: Up to 28 days

2 Burnout and Distress preventiOn With caNnabidiol in Front-line Health Care workerS deAling (Bonsai Study) wIth COVID-19: a Randomised Controlled Trial

The objective of this work is to monitor the level of stress and overload of a group of front-line health workers (physicians, nurses and physiotherapists) who will participate in the care of patients with COVID-19 at Hospital das Clínicas in Ribeirão Preto and its Emergency Unit (HCRP), for four weeks, and evaluate the cannabidiol - CBD's effectiveness in reducing stress for those who wish to use it.

NCT04504877 Covid19 Burn Out Post Traumatic Stress Disorder Drug: Cannabidiol
MeSH:Stress Disorders, Traumatic Stress Disorders, Post-Traumatic

Primary Outcomes

Description: To assess the emotional exhaustion dimension of the burnout syndrome, based on nine items, scored from 0 ("never") to 6 ("every day")

Measure: aMBI-HSS: Abbreviated Maslach Burnout Inventory - Human Services Survey

Time: Through study completion, over time during the study period (day 0-28)

Description: It is a self-report measure widely used to assess PTSD symptoms, according to the DSM-5 criteria. The reduced version of this instrument will be used (8 items)

Measure: Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5)

Time: Through study completion, over time during the study period (day 0-28)

Secondary Outcomes

Description: brief measure for assessing generalized anxiety disorder

Measure: Brief measure for assessing generalized anxiety disorder: The GAD‐7

Time: Through study completion, over time during the study period (day 0-28)

Description: Evaluate depressive symptoms o

Measure: PHQ-9: Patient´s Health Questionnaire-9

Time: Through study completion, over time during the study period (day 0-28)

Description: Laboratory parameters, including the change in proinflammatory cytokine concentrations

Measure: Change in proinflammatory cytokine concentration

Time: Through study completion, over time during the study period (day 0-28)

Description: Occurrence of side effects

Measure: Number of participants with treatment-related adverse events as assessed by CTCAE v5.0

Time: Through study completion, over time during the study period (day 0-28)


No related HPO nodes (Using clinical trials)