CovidResearchTrials by Shray Alag

CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)

PTI-125, 100 mg tabletWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)

Name (Synonyms) Correlation
drug2374 Ravulizumab Wiki 0.71
drug376 Baricitinib Wiki 0.38
drug2707 Standard of care Wiki 0.23

Correlated MeSH Terms (1)

Name (Synonyms) Correlation
D000544 Alzheimer Disease NIH 0.50

Correlated HPO Terms (1)

Name (Synonyms) Correlation
HP:0002511 Alzheimer disease HPO 0.50

There is one clinical trial.

Clinical Trials

1 A 12-Month, Open-Label Safety Study of PTI-125 in Mild-to-moderate Alzheimer's Disease Patients

An Open-label study for patients who completed the previous studies, PTI-125-02 or PTI-125-03. Additional new patients will be included for a total of 100 patients enrolled for this study.

NCT04388254 Alzheimer Disease Drug: PTI-125, 100 mg tablet
MeSH:Alzheimer Disease
HPO:Alzheimer disease

Primary Outcomes

Description: Biomarkers of AD pathology, neurodegeneration and neuroinflammation

Measure: Cerebrospinal fluid P-tau, neurofilament light chain, neurogranin, Total Tau, YKL-40, Abeta42 (pg/mL)

Time: Screening to Month 12

Related HPO nodes (Using clinical trials)

HP:0002511: Alzheimer disease
Genes 13
APP A2M CACNA1G HFE PLAU APOE ABCA7 GATA1 APOE PSEN1 NOS3 PSEN2 MPO
Protein Mutations 5
E280A K56M P200T R199W R38H
SNP 10
rs10524523 rs11870474 rs2227902 rs3742376 rs3745274 rs3796529 rs4900442 rs6971 rs7157609 rs754203