Correlated Drug Terms (0)

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	Name (Synonyms)	Correlation

Correlated MeSH Terms (1)

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	Name (Synonyms)	Correlation
D006967	Hypersensitivity, NIH	0.45

Correlated HPO Terms (1)

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	Name (Synonyms)	Correlation
HP:0012393	Allergy HPO	0.45

Primary Outcomes

Description: Following swallowing of different whey beverage samples (whey protein / whey permeate), volunteers will be asked either to rate samples for mouthdrying or to spit their saliva into a tube at specific timepoints (15s & 60s) with appropriate rest periods. The rating and spitting times will be set within a balanced order protocol.

Measure: Mucoadhesion and Mouthdrying

Time: Saliva collection and mouthdrying scoring throughout visits, 2 days

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Secondary Outcomes

Description: Perceived mouth drying from whey beverages (whey permeate / whey protein) using data from sensory methods (rating drying as well as discrimination tests "which is the stronger in drying"). Scale for scoring is the gLMS scale (general linear magnitude scale); higher value is worse outcome.

Measure: Mouthdrying from whey beverages

Time: 1 day (Sampled at study visit one)

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Description: Volunteers will be asked to manipulate their saliva flow and consume whey beverages (whey permeate / whey protein) and score perceived mouth drying (data will be collected from sensory methods (rating drying as well as discrimination tests "which is the stronger in drying")

Measure: Manipulating saliva flow and mouthdrying from whey beverages

Time: 1 day (Sampled at study visit one)

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Description: Salivary flow rates from unstimulated and stimulated saliva samples.

Measure: Saliva collection

Time: 1 day (Sampled at study visit two)

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HP:0012393: Allergy

Genes 25

MTOR TGM5 COX4I2 PLA2G7 NRXN1 BBS1 CHD1 ADA CNTNAP2 IL4R FOXP3 SIK3 FOXP1 ARL6 MS4A2 RBM8A PGM3 CCDC28B CSTA IL6ST PLCG2 CTLA4 PGM3 SPINK5 CARMIL2

Protein Mutations 5

A118G C677T G20201A L858R P12A

SNP 2

rs11648486 rs1761667