Correlated Drug Terms (2)

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	Name (Synonyms)	Correlation
drug1348	ICU treatment Wiki	1.00
drug3492	theraputic heparin Wiki	1.00

Correlated MeSH Terms (2)

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	Name (Synonyms)	Correlation
D012769	Shock, NIH	0.41
D016638	Critical Illness NIH	0.13

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: which is defined as the number of days that a patient is alive and free of organ support through the first 21 days after trial entry. Organ Support is defined as receipt of non-invasive mechanical ventilation, high flow nasal canula oxygen, mechanical ventilation, or vasopressor therapy, with death at any time during the index hospitalization assigned -1 days.

Measure: 21 Day Organ Support (respiratory or vasopressor) Free Days

Time: 21 days from study enrollment

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Secondary Outcomes

Description: Composite endpoint of death, pulmonary embolism, systemic arterial thromboembolism, myocardial infarction, or ischemic stroke at hospital discharge or 28 days, whichever occurs first

Measure: Key Platform Secondary Thrombotic Endpoint

Time: 28 days from study enrollment

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Description: Acute kidney injury defined by KDIGO criteria, Individual endpoints comprising the key secondary endpoint, death during hospitalization, 28 Day Ventilator-Free Days, 28 Day Vasopressor Free Days, 28 Day Renal Replacement Free Days, WHO clinical scale, 28 Day Hospital Free Days, 28 day organ support free days.

Measure: Other Platform Secondary Endpoints of Morbidity and Hospitalization

Time: 28 days from study enrollment

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Description: Any mortality of patients enrolled within 90 days.

Measure: All cause mortality

Time: 90 days from enrollment

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Other Outcomes

Description: Major bleeding (as defined by the ISTH)

Measure: Primary Safety Endpoint of Major Bleeding

Time: 28 days from study enrollment

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Description: Confirmed heparin induced thrombocytopenia (HIT)

Measure: Secondary Safety Endpoint of HIT

Time: 28 days from study enrollment

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