CovidResearchTrials by Shray Alag

CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)

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Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (2)

Name (Synonyms) Correlation
drug3343 mindfulness, emotion didactics, interpersonal skills, experiential learning Wiki 1.00
drug951 EIT-Group Wiki 1.00

Correlated MeSH Terms (5)

Name (Synonyms) Correlation
D013577 Syndrome NIH 0.10
D012127 Respiratory Distress Syndrome, Newborn NIH 0.09
D012128 Respiratory Distress Syndrome, Adult NIH 0.08
D045169 Severe Acute Respiratory Syndrome NIH 0.05
D018352 Coronavirus Infections NIH 0.04

Correlated HPO Terms (0)

Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials

1 Mechanical Ventilation Strategy for Coronavirus Disease 2019 (COVID-19) - COVEN Study

This is a prospective, randomized, single-center, open-label controlled trial, designed to compare the efficacy of two ventilation strategies (Low Tidal Volume and positive end-expiratory pressure (PEEP) based on the Acute Respiratory Distress Syndrome (ARDS) Network low PEEP-fraction of inspired oxygen inspired oxygen fraction (FIO2) Table versus Low Driving Pressure and PEEP guided by Electrical Impedance Tomography (EIT) in reducing daily lung injury score in patients with acute respiratory distress syndrome caused by COVID-19. The two strategies incorporate different prioritizations of clinical variables. The PEEP-FIO2 table strategy aims to reduce lung overdistension, even if it requires tolerating worse gas exchange. EIT-guided strategy prioritizes mechanical stress protection, avoiding alveolar overdistension and collapse.

NCT04497454 Respiratory Distress Syndrome Severe Acute Respiratory Syndrome Due to Coronavirus (SARS-CoV2) Mechanical Ventilation Other: EIT-Group Other: ARDSNet
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome, Adult Syndrome

Primary Outcomes

Description: This score originally ranges from 0 to 4 points based on the average of 4 parameters (PaO2/FiO2, chest X-Ray, PEEP level, and Respiratory compliance). In the modified version, if the patient dies, he or she automatically receives a score of 5 irrespective of the other four parameters. If the patient is extubated, the score is automatically zero. We also substituted FiO2 for PEEP guaranteeing equivalence of the score when either the low or high PEEP-FiO2 table is applied.

Measure: Average daily Modified Lung injury score until day 28

Time: daily

Secondary Outcomes

Description: Number of days with less than or equal to 1 Liter/min of oxygen supplementation until day 28

Measure: High oxygen dependence free days until day 28

Time: 28 days

Description: Number of days free of mechanical ventilation assistance after protocol inclusion and before day 28

Measure: Mechanical ventilation free days until day 28

Time: 28 days

Description: Occurrence of shock (persistent hypotension despite rescue measures) and incidence of barotrauma

Measure: Incidence of shock or barotrauma

Time: 28 days

Description: Occurrence of acute renal failure that justifies renal replacement therapy

Measure: Incidence of acute renal failure requiring renal replacement therapy

Time: 28 days

Description: Percentage of patients who died in each arm up to 28 days

Measure: 28-day mortality

Time: 28 days

No related HPO nodes (Using clinical trials)