CovidResearchTrials by Shray Alag


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Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (0)


Name (Synonyms) Correlation

Correlated MeSH Terms (3)


Name (Synonyms) Correlation
D013315 Stress, Psychological NIH 0.14
D001008 Anxiety Disorders NIH 0.11
D011014 Pneumonia NIH 0.04

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0002090 Pneumonia HPO 0.04

There are 2 clinical trials

Clinical Trials


1 Study of INFLAmmasome NLRP3 and PLAtelets Functions During Severe COVID-19 Infection

COVID-19 pandemic is a severe viral sepsis characterized by the occurrence of Acute respiratory distress syndrome (ARDS) whose pathophysiology is little described

NCT04397822 COVID-19 Biological: Blood samples

Primary Outcomes

Description: Caspase-1 activity analyzed in patients in intensive care unit and in patients in standard care unit.

Measure: Activation of platelet NLRP3 inflammasome

Time: Day 0 During resuscitation (Covid-19 Resuscitation) or hospitalization (Covid-19 No Resuscitation)

Description: Labeling NOD-like receptor protein 3 (NLRP3)/Adaptor protein aptotosis-associated speck-like protein containing a CARD (ASC) analyzed in patients in intensive care unit and in patients in standard care unit.

Measure: Activation of platelet NLRP3 inflammasome

Time: During Day 0 During resuscitation (Covid-19 Resuscitation) or hospitalization (Covid-19 No Resuscitation)

2 Study of a Possible Respiratory Degradation Prognosis Caused by Biomarkers in Severe Forms of COVID-19 Pneumonia: the LPSARS2 Study

Respiratory infection with the SARS-CoV2 virus is associated with a major risk of viral pneumonia that can lead to respiratory distress requiring resuscitation. In the most severe forms, it may require a mechanical ventilation or even lead to an acute respiratory distress syndrome with a particularly poor prognosis. The SARS-CoV2 is a single-stranded RNA virus of positive polarity and belongs to the beta genus of Coronaviruses. SARS-CoV2 is responsible for the third epidemic in less than twenty years secondary to a Coronavirus (SARS-CoV then MERS-CoV) and if the mortality associated with it is lower than that of previous strains, particularly MERS-CoV (Middle East Respiratory Syndrome), its spread is considerably bigger. As a result, the number of patients developing respiratory distress that require an invasive mechanical ventilation is high, with prolonged ventilation duration in these situations.

NCT04505605 Community-acquired Pneumonia Covid19 Other: Blood samples
MeSH:Pneumonia
HPO:Pneumonia

Primary Outcomes

Description: The study aims at evaluating the interests of the biomarkers dosage: endotoxin (LPS) and circulating cytokines (HMGB1 or RAGE) in the prediction of respiratory degradation through a severe form of COVID-19 acquired pneumonia that requires a hospitalization.

Measure: Evaluation of the dosage of biomarkers

Time: 6 months = study duration

Secondary Outcomes

Description: The study will be also focusing on the search for a correlation between the biomarkers by blood samples that will be taken on each hospitalized patients.

Measure: Link between the biomarkers

Time: 6 months = study duration


Related HPO nodes (Using clinical trials)