CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Emergency LaparotomyWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (0)


Name (Synonyms) Correlation

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D004630 Emergencies NIH 0.18

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Emergency Laparotomies and Outcomes During the COVID-19 Pandemic - a Retrospective Cohort Study

NLR has previously been observed to correlate with complications in upper GI (1) and colorectal (2) surgery. The investigators sought to assess if a similar correlation can be identified in emergency general surgical patients and if the presence of suspected or confirmed COVID-19 may impact on this. Given the heterogeneity of emergency general surgery the investigators therefore plan to perform a retrospective review of patients having emergency laparotomies only at a single NHS site during COVID-19 pandemic. Assessment of outcomes and Neutrophil:lymphocyte ratio as a predictor of outcomes will be completed. Outcomes will be completed in line with the recent COVIDSurg study criteria (3). The primary outcome is 30-day mortality. Secondary outcomes are 7-day mortality, re-operation, length of stay, post-operative respiratory failure, post-operative ARDS (Acute Respiratory Distress Syndrome), post-operative sepsis and ITU (Intensive Therapy Unit)/HDU (High Dependency Unit) admission.

NCT04419571 COVID-19 Emergency General Surgery Procedure: Emergency Laparotomy
MeSH:Emergencies

Primary Outcomes

Description: Mortality

Measure: 30-day mortality

Time: 30 days

Secondary Outcomes

Description: Mortality

Measure: 7-day mortality

Time: 7 days

Description: Re-operation

Measure: Number of participants returning to theatre

Time: 30 days

Description: Inpatient stay during index admission

Measure: Length of stay

Time: 30 days

Description: Presence of respiratory failure in the post-operative period as defined in the clinical notes or discharge summaries

Measure: Post-operative respiratory failure

Time: 30 days

Description: ARDS diagnosed radiologically

Measure: Post-operative ARDS

Time: 30 days

Description: Presence of sepsis in the post-operative period as defined in the clinical notes or discharge summaries

Measure: Post-operative sepsis

Time: 30 days

Description: ITU/HDU admission post-operatively

Measure: ITU/HDU admission

Time: 30 days

Other Outcomes

Description: Other documented post-operative complications

Measure: Other complications

Time: 30 days

Description: Neutrophil:Lymphocyte Ratio will be recorded daily in the peri-operative period

Measure: Peri-operative NLR

Time: First 3 post-operative days

Description: Absolute platelet counts recorded daily in the peri-operative period

Measure: Post-operative platelet counts

Time: First 3 post-operative days

Description: Defined as the presence of increased PT (prothrombin time) OR APTT (activated partial thromboplastin time) OR TT (thrombin time) OR fibrinogen above 1.5X the upper limit of normal. Coagulation will either be defined as normal or abnormal for each patient if one or more of these derangement are identified.

Measure: Post-operative coagulopathy

Time: First 3 post-operative days


No related HPO nodes (Using clinical trials)