SNPMiner Trials by Shray Alag

SNPMiner SNPMiner Trials (Home Page)

Report for Clinical Trial NCT01016444

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

β2AR Polymorphisms and Albuterol Responsiveness in Acute Asthma

The hypothesis to be tested is that acutely ill asthmatics who do not resolve their attacks following standard doses of albuterol and require admission to hospital have single nucleotide polymorphisms of their B2 adrenergic receptors that lower B2 agonist responsivity.

NCT01016444 Acute Asthma
MeSH:Asthma
HPO:Asthma

Primary Outcomes

Measure: B2AR polymorphisms associated with albuterol responsiveness in acute asthma.

Time: ~ 1 hour following 3 doses of albuterol Q 20 min

Secondary Outcomes

Measure: B2AR haplotypes

Time: ~ 1hr post 3 doses of albuterol
Time Perspective: Prospective

Case Control

There are 11 SNPs

SNPs

1 rs1042711

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).

2 rs1042713

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).

3 rs1042714

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).

4 rs1042718

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).

5 rs11958940

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).

6 rs11959427

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).

7 rs12654778

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).

8 rs17778257

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).

9 rs1800888

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).

10 rs2053044

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).

11 rs2895795

Eleven polymorphisms will be selected for genotyping from within the ADRB2 coding region and up to about 5 kb 5' Codon 1 (rs11958940, rs17778257, rs2895795, rs2053044, rs12654778, rs11959427, rs1042711, rs1042713, rs1042714, rs1800888, and rs1042718).


HPO Nodes

HPO:
HP:0002099: Asthma
Genes 143
ZIC2 CCDC103 NODAL DOCK8 DNAAF2 TRAIP CCDC28B OFD1 CCDC151 COL1A1 FOXJ1 SCGB3A2 USP7 RSPH4A ZMYND10 PLA2G7 STXBP1 PEPD CCNO NEK9 SCN4A TNF COL5A2 PLCG2 NOD2 DDX41 TBCK LRRC56 ALMS1 CARMIL2 TGFB1 NKX2-1 COMT DNAH11 ADRB2 DNAI2 ALOX5 SPAG1 ARVCF NFKB2 DRC1 STK36 TGIF1 HYDIN DNAAF3 LIFR DISP1 DNAH9 FLG MUC7 SUFU RSPH9 COL5A1 FCGR2A RPGR DNAH5 DNAL1 CFAP298 TBX1 CCL11 DNAH1 DNAI1 GRHL2 DNAAF1 TBX1 IL4R SIX3 RSPH3 SDHD IL13 GAS2L2 HIRA CFAP221 AFF4 ERCC2 LIG4 GLI2 DNAAF6 DNAAF5 TTC25 CCDC39 NME8 BBS1 CASP8 FGFR1 CARD11 UFD1 DNAAF4 FGF8 PLA2G7 TBX21 RREB1 LRBA TDGF1 PTCH1 MTOR GP9 PGM3 ELOVL4 NKX2-1 BCL11B SPINK5 GP1BB RSPH1 JMJD1C SPINK5 HNMT DLL1 PGM3 LMX1B GAS1 LRRC6 GP1BB COX4I2 SHH CCDC114 PTGER2 FOXH1 GAS8 CFTR NSUN2 SIK3 GP1BA ALMS1 ARMC4 IDS MCIDAS PEX5 ADA MS4A2 CDON TALDO1 CCDC40 CFAP300 SEC24C HLA-G CCDC151 DOCK8 CDSN SPEF2 GTF2H5 DNAJB13 CCDC65
Protein Mutations 4
D299G G16R Q27E T399I
SNP 18
rs1042711 rs1042713 rs1042714 rs1042718 rs11958940 rs11959427 rs12654778 rs12936231 rs1504982 rs17778257 rs1800888 rs1801275 rs1805010 rs2053044 rs2895795 rs324011 rs324015 rs4950928