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Report for Clinical Trial NCT03203486

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

The Effectiveness of a Mediterranean Diet Intervention in NAFLD Clinical Course

The effects of Mediterranean Diet (MedDiet) on clinical, biochemical and inflammatory profile in NAFLD patients with simple steatosis. Potential associations of single nucleotide polymorphisms to diet composition and patients' profile were also investigated.

NCT03203486 NAFLD Steatosis of Liver
MeSH:Non-alcoholic Fatty Liver Disease Fatty Liver
HPO:Hepatic steatosis

1 Interventions

Name: Mediterranean Diet

Description: Participants were instructed to include vegetables, whole grains and fruits in their diet and increase fish, legumes and raw nut intake. Emphasis was given to extra virgin olive oil as the main added fat in meals. Particular attention was drained to decrease fermented dairy and poultry, with small amounts of red meat and homemade sweets. All participants were given meal plans in which the distribution of nutrients in relation to total caloric value was as follows: 40% of total energy as fat (50% as MUFAs), 20% as protein, 40% as carbohydrate, 300mg/d as dietary cholesterol and 20-30g fiber/d.
Type: Other
Group Labels: 1

Meditteranean Diet


Primary Outcomes

Description: A decrease in liver fat

Measure: Regulation of hepatic steatosis

Time: Change from Baseline to 6 months

Secondary Outcomes

Description: Increase in MedDietScore

Measure: Adherence to MedDiet

Time: Change from Baseline to 6 months

Description: Decrease in visfatin levels

Measure: Regulation of visfatin

Time: Change from Baseline to 6 months

Description: Decrease in oxLDL levels

Measure: Regulation of oxLDL

Time: Change from Baseline to 6 months

Description: Decrease in visfatin in carriers of the risk allele

Measure: Association of single nucleotide polymorphisms to response to dietary treatment

Time: Change from Baseline to 6 months

Purpose: Other

Allocation: N/A

Single Group Assignment


There are 2 SNPs

SNPs


1 rs1260326

Furthermore, genotyping of STAT3 rs2293152 and GCKR rs1260326 single nucleotide polymorphisms takes place.


2 rs2293152

Furthermore, genotyping of STAT3 rs2293152 and GCKR rs1260326 single nucleotide polymorphisms takes place.



HPO Nodes


HPO: