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Report for Clinical Trial NCT03203486

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

The Effectiveness of a Mediterranean Diet Intervention in NAFLD Clinical Course

The effects of Mediterranean Diet (MedDiet) on clinical, biochemical and inflammatory profile in NAFLD patients with simple steatosis. Potential associations of single nucleotide polymorphisms to diet composition and patients' profile were also investigated.

NCT03203486 NAFLD Steatosis of Liver
MeSH:Non-alcoholic Fatty Liver Disease Fatty Liver
HPO:Hepatic steatosis

1 Interventions

Name: Mediterranean Diet

Description: Participants were instructed to include vegetables, whole grains and fruits in their diet and increase fish, legumes and raw nut intake. Emphasis was given to extra virgin olive oil as the main added fat in meals. Particular attention was drained to decrease fermented dairy and poultry, with small amounts of red meat and homemade sweets. All participants were given meal plans in which the distribution of nutrients in relation to total caloric value was as follows: 40% of total energy as fat (50% as MUFAs), 20% as protein, 40% as carbohydrate, 300mg/d as dietary cholesterol and 20-30g fiber/d.
Type: Other
Group Labels: 1

Meditteranean Diet

Primary Outcomes

Description: A decrease in liver fat

Measure: Regulation of hepatic steatosis

Time: Change from Baseline to 6 months

Secondary Outcomes

Description: Increase in MedDietScore

Measure: Adherence to MedDiet

Time: Change from Baseline to 6 months

Description: Decrease in visfatin levels

Measure: Regulation of visfatin

Time: Change from Baseline to 6 months

Description: Decrease in oxLDL levels

Measure: Regulation of oxLDL

Time: Change from Baseline to 6 months

Description: Decrease in visfatin in carriers of the risk allele

Measure: Association of single nucleotide polymorphisms to response to dietary treatment

Time: Change from Baseline to 6 months
Purpose: Other

Allocation: N/A

Single Group Assignment

There are 2 SNPs

SNPs

1 rs1260326

Furthermore, genotyping of STAT3 rs2293152 and GCKR rs1260326 single nucleotide polymorphisms takes place.

2 rs2293152

Furthermore, genotyping of STAT3 rs2293152 and GCKR rs1260326 single nucleotide polymorphisms takes place.


HPO Nodes

HPO:
HP:0001397: Hepatic steatosis
Genes 137
SLC40A1 LDLR TARS2 ABCG8 DNAJC19 PNPLA2 DNAJC19 APOB PMM2 CAV1 LRPPRC PRDM16 CPT2 LMNA HSD17B4 POLG NDUFAF1 SKI BSCL2 CYP19A1 SAR1B SLC25A13 CIDEC KCNAB2 ACADVL GABRD ALMS1 COA8 AGPAT2 POLG ETFDH ETFA PPARG BSCL2 PNPLA2 AKT2 BCS1L ZMPSTE24 POLR3A PCK2 BCS1L HNF4A TYMP MRPL44 LMNA SLC25A13 DDOST RERE TRMU MARS1 LIPA COG6 CPT2 PHKA2 MPV17 ACAD9 MCCC1 LIPE TRAPPC11 APOE ATP7B NSMCE2 HFE TFAM COX15 CAV1 CEP19 LMNA HADHB EARS2 PGM1 CBS ACADL HADH BSCL2 LIPE ALDOB ADK LMNB2 ACADM HNRNPA2B1 CAVIN1 PPARG RRM2B CYP7A1 CAVIN1 FBP1 PLIN1 FOS TMEM199 CARS2 ACOX1 SLC22A5 LMNA MRPS7 HADH IARS1 XRCC4 CPT1A PPARG DGUOK PTRH2 ABHD5 NSMCE2 ACAD9 VCP GPD1 FARSB ATP6AP1 SLC25A13 TRAPPC11 RMND1 HADHA PHKG2 MPV17 LMNA POLD1 ACADM PCSK9 ALMS1 CIDEC ABHD5 LARS1 VPS33A CLPB LYRM4 PCK1 PLIN1 HNRNPA1 NGLY1 LMNA HNF1B ABCG5 SLC40A1 ETFB AGPAT2 LDLRAP1
Protein Mutations 4
C282Y E167K H63D I148M
SNP 10
rs1260326 rs2281135 rs2293152 rs2294918 rs2854116 rs2854117 rs58542926 rs641738 rs73049 rs738409