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Report for Clinical Trial NCT04145453

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults

The main goal of the project is to test whether the TAS2R38 polymorphism affects the effectiveness of dietary intervention aimed at increasing the consumption of vegetables and citrus fruits.

NCT04145453 Healthy Lifestyle Taste Disorders Diet Habit
MeSH:Taste Disorders

1 Interventions

Name: Intervention

Description: Participants will receine general nutritional recommendations to increase fruit and vegetables consumption
Type: Behavioral
Group Labels: 1

intervention group

Primary Outcomes

Description: Change in frequency of vegatables intake within the group and between the groups; Block vegetables intake screener

Measure: Vegetables intake

Time: Baseline, 8 weeks

Description: genotyping of polymorphism TAS2R38 gene (rsr713598, rs1726866, and rs10246939)

Measure: TAS2R38 polymorphism

Time: baseline

Secondary Outcomes

Description: change in body mass (kg) within the group and between the groups

Measure: Body Mass (BM)

Time: Baseline, 8 weeks

Description: change in FFM (kg) within the group and between the groups

Measure: Fat free mass (FFM)

Time: Baseline, 8 weeks

Description: change in Fat Mass % within the group and between the groups

Measure: Fat Mass (FM) %

Time: Baseline, 8 weeks

Description: Change in WC (cm) within the group and between the groups

Measure: Waist circumference (WC)

Time: Baseline, 8 weeks

Description: Changes in TChol (mg/dl) within the group and between the groups

Measure: Total Cholesterol (TChol)

Time: Baseline, 8 weeks

Description: Changes in LDL-Chol (mg/dl) within the group and between the groups

Measure: LDL Cholesterol(LDL-Chol)

Time: Baseline, 8 weeks

Description: Changes in HDL-Chol (mg/dl) within the group and between the groups

Measure: HDL Cholesterol (HDL-Chol)

Time: Baseline, 8 weeks

Description: Changes in TG (mg/dl) within groups and between groups

Measure: Triglycerides (TG)

Time: Baseline, 8 week

Description: Changes in GLU (mg/dl) within the group and between the groups

Measure: Glucose (GLU)

Time: Baseline, 8 weeks

Description: Changes in INS (ulU/ml) within the group and between the groups

Measure: Insulin (INS)

Time: Baseline, 8 weeks

Description: Changes in ALAT (U/l) within the group and between the groups

Measure: Alanine transaminase (ALAT)

Time: Baseline, 8 weeks

Description: Changes in ASPAT (U/l) within the group and between the groups

Measure: aspartate aminotransferase (ASPAT)

Time: Baseline, 8 weeks
Purpose: Basic Science

Allocation: N/A

Single Group Assignment

There are 2 SNPs

SNPs

1 rs10246939

genotyping of polymorphism TAS2R38 gene (rsr713598, rs1726866, and rs10246939).

2 rs1726866

genotyping of polymorphism TAS2R38 gene (rsr713598, rs1726866, and rs10246939).


HPO Nodes