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Report for Clinical Trial NCT01924052

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

CGRP Induced Migraine Attacks in Patients With High and Low Genetic Load

The investigators hypothesized that migraine without patients with many genetic loci associated with migraine (high genetic load) would be more sensitive and get provoked more migraine attacks by calcitonin gene-related peptide (CGRP) compared to patients with few genetic loci associated with migraine (low genetic load).

NCT01924052 Migraine Without Aura
MeSH:Migraine Disorders Migraine without Aura
HPO:Migraine Migraine without aura

1 Interventions

Name: CGRP

Description: Calcitonin-gene-related-peptide (CGRP)
Type: Drug
Group Labels: 2

Migraine patients with high genetic load Migraine patients with low genetic load


Primary Outcomes

Description: The difference in incidence of migraine-like attacks between patients with high genetic load and patients with low genetic load using verbal rating scale (VRS).

Measure: CGRP induced migraine attacks in patients with high and low genetic load

Time: Change from baseline in headache intensity at 12 hours after the start of infusion of CGRP

Secondary Outcomes

Description: The difference in area under the curve (AUC) for headache intensity scores (0-12 hours)

Measure: CGRP induced migraine attacks in patients with high and low genetic load

Time: Change from baseline in headache intensity at 12 hours after the start of infusion of CGRP

Allocation: Non-Randomized

Parallel Assignment


There is one SNP

SNPs


1 rs13208321

One of the genetic loci (rs13208321) is located in a gene (FHL5) that is associated with the regulation of cAMP-responsive elements.



HPO Nodes


HPO: