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Report for Clinical Trial NCT01924052

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

CGRP Induced Migraine Attacks in Patients With High and Low Genetic Load

The investigators hypothesized that migraine without patients with many genetic loci associated with migraine (high genetic load) would be more sensitive and get provoked more migraine attacks by calcitonin gene-related peptide (CGRP) compared to patients with few genetic loci associated with migraine (low genetic load).

NCT01924052 Migraine Without Aura
MeSH:Migraine Disorders Migraine without Aura
HPO:Migraine Migraine without aura

1 Interventions

Name: CGRP

Description: Calcitonin-gene-related-peptide (CGRP)
Type: Drug
Group Labels: 2

Migraine patients with high genetic load Migraine patients with low genetic load

Primary Outcomes

Description: The difference in incidence of migraine-like attacks between patients with high genetic load and patients with low genetic load using verbal rating scale (VRS).

Measure: CGRP induced migraine attacks in patients with high and low genetic load

Time: Change from baseline in headache intensity at 12 hours after the start of infusion of CGRP

Secondary Outcomes

Description: The difference in area under the curve (AUC) for headache intensity scores (0-12 hours)

Measure: CGRP induced migraine attacks in patients with high and low genetic load

Time: Change from baseline in headache intensity at 12 hours after the start of infusion of CGRP
Allocation: Non-Randomized

Parallel Assignment

There is one SNP

SNPs

1 rs13208321

One of the genetic loci (rs13208321) is located in a gene (FHL5) that is associated with the regulation of cAMP-responsive elements.


HPO Nodes

HPO:
HP:0002076: Migraine
Genes 181
NOP56 TRNF SLC25A4 ACVRL1 PIK3CA KCNQ3 POLG COL3A1 KCNQ2 COL1A1 GABRG2 MLX CSNK1D TLR4 ND5 APP RPS15A TRNV GPR101 RPL11 EPCAM TRNS2 CACNA1A NF2 RPS19 RPL35A RRM2B KRAS STAT4 KLRC4 ACVRL1 POLG NOTCH3 IL10 TSR2 COL5A2 PRRT2 TRNL1 IL12A PRRT2 GDF2 PMS2 TRNL1 FGFR3 COX3 ADA2 MYORG PDGFB AIP CACNA1A RPS29 EDNRA NLRP3 ENG SLC1A3 TRNS1 C11ORF95 RELA TWNK GCDH SCN8A TRNF TRNW COX3 TGFBR2 HTR1A RPS24 IL12A-AS1 ERAP1 RPS20 TNFRSF1A RPL18 SCN8A KCNA1 MYD88 COL5A1 TREX1 DNM1L TRNH OPA1 COX1 GATA2 TRNW ADAMTSL1 RPL15 SLC6A19 CACNA1A SCN2A PRRT2 ND1 CYTB PGK1 FGFR3 ND5 TWNK TWIST1 SMARCB1 RRM2B ND4 RPS10 PEX11B TREX1 COX2 MVK TRNQ TRNS2 RPS27 SMAD3 RPS26 SLC2A1 SH2B1 SEMA4A FGFR2 COX1 CACNA1A TWNK SLC2A1 CACNA1A NFIX RPS28 RPL5 FAN1 GP9 ATP1A2 IL12B PGK1 FAS APP CCR1 HLA-B ND1 TRNQ NDP VHL GP1BB SRPX2 RPS7 TNF RPL35 PDGFRB STIM1 SMAD4 MLH1 RPS17 MSH2 ESR1 MEFV C4A BMPR1A UBAC2 ADA2 GATA1 TWNK SCN1A GP1BA ND6 GRIN2A ACSF3 TRNS1 RNASEH1 RPL26 RPL31 AMACR IL23R PMS1 MLH3 ND6 NOTCH3 SLC1A3 COX2 COL4A1 RPL27 PRRT2 POLG2 POLG HLA-B TRNK NLRC4 MSH6 ENG TRNC
Protein Mutations 2
C325G G594A
SNP 1
rs13208321
HP:0002083: Migraine without aura
Genes 4
CSNK1D TNF EDNRA ESR1
Protein Mutations 0
SNP 1
rs13208321