In a study of Cardiac sarcoidosis, a serious heart condition, a radiotracer is being used to examine inflammation.
Name: 11C-PBR PET
Description: The primary outcome of this study will be the ratio of 11C-PBR28 PET activity in myocardial regions with inflammation indicated by FDG PET and/or edema indicated by increased T2 signal with cardiac MRI compared to the 11C-PBR28 PET activity in myocardial segments which appear normal on FDG PET and cardiac MRI. The primary outcome is thus the intensity of uptake in abnormal regions as a percentage of the intensity of uptake in normal segments.Measure: Ratio of 11C-PBR28 in the Myocardium Time: 1 hour scan
Description: As a secondary outcome of this study we will evaluate the ratio of 11C-PBR28 PET activity in regions with fibrosis indicated by decreased myocardial perfusion on 82Rb PET and/or late gadolinium enhancement on cardiac MRI without imaging signs of active inflammation compared to 11C-PBR28 PET activity in myocardial segments which appear normal on 82Rb PET, FDG PET and cardiac MRI. This outcome will thus be expressed by 11C-PBR28 PET uptake in fibrotic regions as a percentage of uptake in normal segments We will also evaluate the concordance between extracardiac activity seen in 11C-PBR28 and FDG PET, and when available, histopathology of contemporaneous biopsy specimens.Measure: The Ratio of 11C-PBR28 PET Activity in Cardiac Regions With Fibrosis Time: 1 hour scan
Single Group Assignment
There is one SNP
If you have two copies of a genetic variation called rs6971 which will prevent this tracer from generating high-quality images you may not participate.