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Report for Clinical Trial NCT03702205

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

The Effect of Betaine Supplementation on Body Composition and Physical Capacity of Speed-strength Male Athletes

The study is aimed at assessing the influence of two betaine doses (2.5 g∙d-1 and 5 g∙d-1) supplemented for three weeks in a group of speed-strength trained athletes on anaerobic capacity in Wingate test, performance in CrossFit-like exercise test - Fight Gone Bad, alterations in body compositions and total body water.

NCT03702205 Supplementation Sport

2 Interventions

Name: Betaine supplementation

Description: Group taking oral betaine supplementation
Type: Dietary Supplement
Group Labels: 2

Betaine supplementation Placebo treatment

Name: Placebo treatment

Description: Group taking oral supplementation with placebo (starch) in a similar capsule form.
Type: Dietary Supplement
Group Labels: 2

Betaine supplementation Placebo treatment

Primary Outcomes

Description: Fat mass (kg) and fat free mass (kg) analysis

Measure: Changes in fat mass and fat free mass after betaine supplementation

Time: Baseline and after 3 weeks

Description: The Wingate cycling test (W)

Measure: Changes in anaerobic capacity after betaine supplementation

Time: Baseline and after 3 weeks

Description: The CrossFit-specific physical fitness test: Fight Gone Bad (reps.)

Measure: Changes in specific performance capacity after betaine supplementation

Time: Baseline and after 3 weeks

Secondary Outcomes

Description: Total body water content (%)

Measure: Changes in total body water after betaine supplementation

Time: Baseline and after 3 weeks

Description: Testosterone level (ng/L)

Measure: Changes in testosterone level (ng/L) after betaine supplementation

Time: Baseline and after 3 weeks

Description: Amino acid profile (μmol/L)

Measure: Changes in amino acid profile after betaine supplementation

Time: Baseline and after 3 weeks

Description: Blood betaine (µmol/L)

Measure: Changes in blood betaine

Time: Baseline and after 3 weeks

Description: Total, LDL and HDL cholesterol (mg/dL) and triacylglycerol (mg/dL)

Measure: Changes in total, LDL and HDL cholesterol and triacylglycerol after betaine supplementation

Time: Baseline and after 3 weeks

Description: MTHFR (rs1801133) polymorphism

Measure: Difference in response to betaine supplementation depending on MTHFR (rs1801133) polymorphism

Time: Baseline and after 3 weeks
Purpose: Treatment

Allocation: Randomized

Crossover Assignment

There is one SNP

SNPs

1 rs1801133

Difference in response to betaine supplementation depending on MTHFR (rs1801133) polymorphism.

MTHFR (rs1801133) polymorphism.


HPO Nodes