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Report for Clinical Trial NCT02197624

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Metabolic Adaptation to Plant-based Diets in Asian Populations

The two specific aims of this study are: 1) to assess the impact of a genetic variant on iron status; 2) to assess the impact of a genetic variant on non-heme absorption among Asian women. The investigators hypothesize that the genetic variant could enhance iron status and iron absorption in Asian women.

NCT02197624 Iron Absorption


Primary Outcomes

Description: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining genotype.

Measure: Genotype at SNP rs9366637

Time: 2 weeks after the participant's visit to the laboratory

Description: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of hemoglobin.

Measure: Hemoglobin

Time: Up to 2 days after the participant's visit to the laboratory

Description: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of serum ferritin.

Measure: Serum Ferritin

Time: Up to 6 months after the participant's visit to the laboratory

Description: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of serum transferrin receptor.

Measure: Serum transferrin receptor

Time: Up to 6 months after the participant's visit to the laboratory

Description: Women donated a blood sample for genotyping. Women with particular HFE genotypes were invited to return for an absorption study. Two weeks after women consume the iron tracer, a blood sample was obtained to measure the amount of iron absorbed.

Measure: Non-heme Iron absorption in women with 2 HFE genotypes

Time: one month for screening with genotype then 2 weeks for iron absorption study

Secondary Outcomes

Description: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of folate.

Measure: Folate

Time: Up to 6 months after the participant's visit to the laboratory

Description: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of vitamin B-12.

Measure: Vitamin B-12

Time: Up to 6 months after the participant's visit to the laboratory

Description: At the participant's visit to the laboratory, a 10 mL blood sample was collected. The blood sample was used for determining the concentration of C-reactive protein.

Measure: C-reactive protein

Time: Up to 6 months after the participant's visit to the laboratory

Time Perspective: Prospective

Case-Only


There is one SNP

SNPs


1 rs9366637

Genotype at SNP rs9366637.



HPO Nodes