SNPMiner Trials (Home Page)
Report for Clinical Trial NCT01989351
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
LA PREDISPOSIZIONE AL DOLORE PERSISTENTE POST OPERATORIO IN AMBITO ORTOPEDICO: ASPETTI GENETICI
The study purpose is to examine polymorphism of genes associated to post-operative persistent pain and to verify the possible association between genotype phenotype and ADRB2 polymorphism in orthopaedic surgery. The primary aim is to evaluate the expression of ADBR2 in VAS>4 patients and to compare it to those with VAS<4.
NCT01989351 Chronic Pain MeSH:Chronic Pain
HPO:Chronic pain
Primary Outcomes
Measure: Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients. Time: 4 months after surgery
Secondary Outcomes
Measure: Expression frequency of OPRM1, COMT, IL1Ra Time: 6, 12, 24, 48 hours
Measure: Serum concentration of TNFα, TGFβ, IFNγ, IL-6 and IL-10 obtained with ELISA system Time: 6, 12, 24 and 48 hours postoperatively
Time Perspective: Prospective
Primary Outcomes
Measure: Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients. Time: 4 months after surgerySecondary Outcomes
Measure: Expression frequency of OPRM1, COMT, IL1Ra Time: 6, 12, 24, 48 hoursMeasure: Serum concentration of TNFα, TGFβ, IFNγ, IL-6 and IL-10 obtained with ELISA system Time: 6, 12, 24 and 48 hours postoperatively
Cohort
There are 2 SNPs
SNPs
1 rs1042713
Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients.. null.
2 rs12654788
Frequency of SNPs rs12654788 and rs1042713 of ADBR2 gene in patients who complain persistent pain 4 months postoperatively compared to chronic pain free patients.. null.