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Report for Clinical Trial NCT03154242

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Effect of Genetic Polymorphisms on Clinical Outcome of Platinum Based Chemotherapy in Non-Small Cell Lung Cancer Patients

This Study evaluate the effect of Polymorphism in the Excision repair cross-complementing group 5 (ERCC5) (rs1047768 and rs751402) gene on the clinical outcome of Platinum-based regimens used in the treatment of Non-Small Cell Lung Cancer (NSCLC) patients

NCT03154242 Carcinoma, Non-Small-Cell Lung
MeSH:Lung Neoplasms Carcinoma, Non-Small-Cell Lung
HPO:Neoplasm of the lung Non-small cell lung carcinoma

Primary Outcomes

Description: It's defined as the time from day 1 of chemotherapy to the day of documented disease progression or death from any cause.

Measure: Progression-free survival (PFS)

Time: From the date of starting the chemotherapy until the date of documented disease progression or date of death from any cause assessed up to 12 months
Time Perspective: Prospective

Other

There are 2 SNPs

SNPs

1 rs1047768

Effect of Genetic Polymorphisms on Platinum Based Chemotherapy in Non Small Cell Lung Cancer This Study evaluate the effect of Polymorphism in the Excision repair cross-complementing group 5 (ERCC5) (rs1047768 and rs751402) gene on the clinical outcome of Platinum-based regimens used in the treatment of Non-Small Cell Lung Cancer (NSCLC) patients Progression-free survival (PFS).

2 rs751402

Effect of Genetic Polymorphisms on Platinum Based Chemotherapy in Non Small Cell Lung Cancer This Study evaluate the effect of Polymorphism in the Excision repair cross-complementing group 5 (ERCC5) (rs1047768 and rs751402) gene on the clinical outcome of Platinum-based regimens used in the treatment of Non-Small Cell Lung Cancer (NSCLC) patients Progression-free survival (PFS).


HPO Nodes

HPO:
HP:0100526: Neoplasm of the lung
Genes 62
TP53 SLCO2A1 STAT6 WT1 BRAF HPGD TSC1 PRKN CYP2A6 PPP2R1B LMNA MUC5B PIK3CA DIS3L2 CASP8 STK11 H19 BRCA2 NOTCH3 WT1 SFTPA2 TSC2 FASLG BAP1 WRN ERCC6 MBTPS2 DICER1 C11ORF95 TRIM28 RB1 GPC3 RELA PERP SFTPC SLC22A18 PDGFRB ERBB2 TSC2 PTEN TRIP13 EWSR1 MAP3K8 TSC1 TRPV3 DICER1 TERT TRIM28 IRF1 REST TSC1 TP53 KEAP1 DICER1 AKT1 KRAS POU6F2 NAB2 TSC1 WT1 EGFR TSC2
Protein Mutations 52
C1156Y C797S D594G F1174C F1174V G1202R G1269A G12C G12D G469A G719A G719C G719S G776C G776V I10A L1196M L1198F L523S L755S L833F L8585R L858R L859R L861G L861Q L861R N375S P13K P4503A R776G R831C S1400A S1400C S1400D S1400E S1400F S1400G S1400I S1400K S1800A S1900A S1900C S1900D S768I T790M T81C T890M V600E V769L V777L V843I
SNP 6
rs1047768 rs10937405 rs11045585 rs12762549 rs4488809 rs751402
HP:0030358: Non-small cell lung carcinoma
Genes 3
TP53 TP53 BAP1
Protein Mutations 43
C797S C8092A D594G F1174C F1174V G1202R G1269A G12C G12D G12V G13D G2032R G469A G719A G719C G719S G776C G776V I10A L1196M L523S L755S L833F L8585R L858R L861G L861Q L861R P13K P4503A R776G R831C S1800A S1900A S1900C S768I T790M T81C V600E V600K V769L V777L V843I
SNP 2
rs1047768 rs751402