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Report for Clinical Trial NCT01585948
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
The Role of Newer and Traditional Risk Factors in the Development, Extent and Manifestation of Coronary Artery Disease
In the present study the investigators will measure the extent of coronary artery disease via coronary angiography and the correlating risk factors.
NCT01585948 Patients Undergoing Coronary Angiography MeSH:Coronary Artery Disease Myocardial Ischemia Coronary Disease
HPO:Coronary artery atherosclerosis Myocardial infarction
Primary Outcomes
Description: We will investigate the incidence, extent and clinical manifestation of coronary artery disease in diabetics and non-diabetics undergoing coronary angiography for clinical reasons.
Measure: The incidence and extent of coronary artery disease between diabetics and non-diabetic patients. Time: Up to four years on average.
Secondary Outcomes
Description: To associate the incidence, extent and clinical manifestation of coronary artery disease with classic demographic risk factors (such as smoking, alcohol consumption, physical exercise, arterial hypertension, family history of diabetes mellitus or coronary artery disease) and common biochemical risk factors (such as fasting glucose levels, urea, creatinine, HbA1c%, uric acid, total cholesterol, HDL, LDL, triglycerides, VLDL, glomerular filtration rate - GFR).
Measure: The incidence and extent of coronary artery disease via coronary angiography scores and related biochemical and demographical risk factors. Time: Up to 4 years on average.
Description: To associate the incidence, extent and clinical manifestation of coronary artery disease with systemic inflammatory status assessed by hs-CRP levels, circulating adipokines (adiponectin, resistin) and the receptors of advanced glycation end products (sRAGE and esRAGE).
Measure: The incidence, extent and clinical manifestation of coronary artery disease and the circulating levels of hs-CRP, adipokines and RAGEs. Time: Up to 4 years on average.
Description: To associate the incidence, extent and clinical manifestation of coronary artery disease with the rs7903146 single nucleotide polymorphism of TCF7L2 gene, that has been strongly associated with diabetes mellitus development.
Measure: TCF7L2 gene polymorphims and the incidence and extent of coronary artery disease. Time: Within a maximum period of 4 years.
Time Perspective: Cross-Sectional
Primary Outcomes
Description: We will investigate the incidence, extent and clinical manifestation of coronary artery disease in diabetics and non-diabetics undergoing coronary angiography for clinical reasons.
Measure: The incidence and extent of coronary artery disease between diabetics and non-diabetic patients. Time: Up to four years on average.Secondary Outcomes
Description: To associate the incidence, extent and clinical manifestation of coronary artery disease with classic demographic risk factors (such as smoking, alcohol consumption, physical exercise, arterial hypertension, family history of diabetes mellitus or coronary artery disease) and common biochemical risk factors (such as fasting glucose levels, urea, creatinine, HbA1c%, uric acid, total cholesterol, HDL, LDL, triglycerides, VLDL, glomerular filtration rate - GFR).
Measure: The incidence and extent of coronary artery disease via coronary angiography scores and related biochemical and demographical risk factors. Time: Up to 4 years on average.Description: To associate the incidence, extent and clinical manifestation of coronary artery disease with systemic inflammatory status assessed by hs-CRP levels, circulating adipokines (adiponectin, resistin) and the receptors of advanced glycation end products (sRAGE and esRAGE).
Measure: The incidence, extent and clinical manifestation of coronary artery disease and the circulating levels of hs-CRP, adipokines and RAGEs. Time: Up to 4 years on average.Description: To associate the incidence, extent and clinical manifestation of coronary artery disease with the rs7903146 single nucleotide polymorphism of TCF7L2 gene, that has been strongly associated with diabetes mellitus development.
Measure: TCF7L2 gene polymorphims and the incidence and extent of coronary artery disease. Time: Within a maximum period of 4 years.Case-Control
There is one SNP
SNPs
1 rs7903146
The incidence, extent and clinical manifestation of coronary artery disease and the circulating levels of hs-CRP, adipokines and RAGEs.. To associate the incidence, extent and clinical manifestation of coronary artery disease with systemic inflammatory status assessed by hs-CRP levels, circulating adipokines (adiponectin, resistin) and the receptors of advanced glycation end products (sRAGE and esRAGE).. TCF7L2 gene polymorphims and the incidence and extent of coronary artery disease.. To associate the incidence, extent and clinical manifestation of coronary artery disease with the rs7903146 single nucleotide polymorphism of TCF7L2 gene, that has been strongly associated with diabetes mellitus development.. Inclusion Criteria: - Any subject eligible for coronary angiography with or without known CV disease for clinical reasons.