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Report for Clinical Trial NCT01682655
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
The Influence of Apolipoprotein C3 Variants on Liver Steatosis and Serum Liver Enzyme Values in Obese Children
In the past decades, obesity in children is much more prevalent in the world. Given the increasing prevalence of pediatric obesity worldwide, fatty liver incidence is on the rise. Genetic variant in apolipoprotein C3 (APOC3) gene is associated with increased liver fat content in adults. The aim of this study is to find out whether APOC3 single nucleotide polymorphism (SNP) influence fatty liver in obese children and adolescent.
NCT01682655 Fatty Liver Obesity MeSH:Fatty Liver
HPO:Hepatic steatosis
Primary Outcomes
Measure: genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis Time: Oct 2013 ~ Dec 2014
Secondary Outcomes
Measure: genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance Time: Oct 2013 ~ Dec 2014
Time Perspective: Prospective
Primary Outcomes
Measure: genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis Time: Oct 2013 ~ Dec 2014Secondary Outcomes
Measure: genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance Time: Oct 2013 ~ Dec 2014Cohort
There are 2 SNPs
SNPs
1 rs2854116
genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis.
genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance.
Inclusion Criteria: - Age 6-18 years old - Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan - Willing to give written informed consent by parents Exclusion Criteria: - Alcohol consumption - Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis - Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder Inclusion Criteria: - Age 6-18 years old - Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan - Willing to give written informed consent by parents Exclusion Criteria: - Alcohol consumption - Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis - Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder Fatty Liver Obesity Fatty Liver The primary aim of this study is to assess the associations between to investigate the association of rs2854117 C > T and rs2854116 T > C SNPs of the APOC3 gene with liver steatosis, as measured by liver ultrasound.
As a secondary aim, the investigators will examine the associations between APOC3 rs2854117 C > T and rs2854116 T > C SNPs and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels.
2 rs2854117
genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without liver steatosis.
genotype distribution of APOC3 rs2854117 and rs2854116 polymorphisms in subjects with and without insulin resistance.
Inclusion Criteria: - Age 6-18 years old - Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan - Willing to give written informed consent by parents Exclusion Criteria: - Alcohol consumption - Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis - Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder Inclusion Criteria: - Age 6-18 years old - Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan - Willing to give written informed consent by parents Exclusion Criteria: - Alcohol consumption - Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis - Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder Fatty Liver Obesity Fatty Liver The primary aim of this study is to assess the associations between to investigate the association of rs2854117 C > T and rs2854116 T > C SNPs of the APOC3 gene with liver steatosis, as measured by liver ultrasound.
As a secondary aim, the investigators will examine the associations between APOC3 rs2854117 C > T and rs2854116 T > C SNPs and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels.