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Report for Clinical Trial NCT01108250

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy in a Korean Population

This study is to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy and whether they are associated with clinical patterns including angiographic phenotype in a Korean population.

NCT01108250 Age-Related Macular Degeneration
MeSH:Macular Degeneration

1 Interventions

Name: LOC387715/HTRA1 genotyping

Description: Genomic DNA was extracted from whole blood by standard methods. Genotyping was performed using SNP Genotyping Assays.
Type: Genetic
Group Labels: 2

control polypoidal choroidal vasculopathy

Primary Outcomes

Description: to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy (PCV)

Measure: Genotyping of LOC387715/HTRA1 of PCV and control groups

Time: 4weeks

Secondary Outcomes

Description: The association of the risk allele of the LOC387715/HTRA1 and indocyanine angiographic characteristics of polypoidal choroidal vasculopathy including subretinal hemorrhage, pigment epithelial detachment, and serous retinal detachment.

Measure: Indocyanine angiographic findings of polypoidal choroidal vasculopathy

Time: 20 minutes

Description: To evaluate the association between visual acuity and genotype of polypoidal choroidal vasculopathy

Measure: Visual acuity using Snellen chart

Time: 2 x 5 minutes
Purpose: Basic Science

Allocation: Non-Randomized

Parallel Assignment

There are 2 SNPs

SNPs

1 rs10490924

One hundred Korean patients with polypoidal choroidal vasculopathy and 100 control subjects were genotyped for the LOC387715 (rs10490924) and the HTRA1 gene polymorphism (rs11200638)

2 rs11200638

One hundred Korean patients with polypoidal choroidal vasculopathy and 100 control subjects were genotyped for the LOC387715 (rs10490924) and the HTRA1 gene polymorphism (rs11200638)


HPO Nodes