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Report for Clinical Trial NCT03968445
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
Neuroinflammation After Myocardial Infarction - Imaging Substudy
The purpose of the study is to see if positron emission tomography and magnetic resonance imaging (PET/MRI) with an investigational drug called [18F]DPA-714 will show inflammation in the brain after a heart attack. This study may help physicians and researchers better understand the role of brain inflammation in heart disease and develop new treatments to protect the brain.
NCT03968445 Myocardial Infarction MeSH:Myocardial Infarction Infarction
HPO:Myocardial infarction
1 Interventions
Name: [18F]DPA-714-PET/MRI
Primary Outcomes
Description: The regional brain concentrations of [F-18]DPA-714, a PET imaging marker of neuroinflammation, will be compared between study participants who have recently been hospitalized for acute myocardial infarction (AMI) and a control group undergoing elective percutaneous coronary interventions (PCI).
Measure: TPSO-PET measurement of neuroinflammation after acute myocardial infarction Time: 2 yearsPurpose: Diagnostic
Allocation: Non-Randomized
Single Group Assignment
There is one SNP
SNPs
1 rs6971
English speaking with at least 8th grade education 4. High or mixed affinity binder for TSPO ligands based on genotyping for single nucleotide polymorphism (SNP) rs6971.
Diagnosis of dementia 12. Low affinity binder for TSPO ligands based on genotyping for SNP rs6971.