SNPMiner Trials by Shray Alag

SNPMiner SNPMiner Trials (Home Page)

Report for Clinical Trial NCT03968445

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Neuroinflammation After Myocardial Infarction - Imaging Substudy

The purpose of the study is to see if positron emission tomography and magnetic resonance imaging (PET/MRI) with an investigational drug called [18F]DPA-714 will show inflammation in the brain after a heart attack. This study may help physicians and researchers better understand the role of brain inflammation in heart disease and develop new treatments to protect the brain.

NCT03968445 Myocardial Infarction
MeSH:Myocardial Infarction Infarction
HPO:Myocardial infarction

1 Interventions

Name: [18F]DPA-714-PET/MRI

Description: [18F]DPA-714-PET/MRI
Type: Drug
Group Labels: 2

Recent Myocardial Infarction undergoing elective percutaneous coronary intervention

Primary Outcomes

Description: The regional brain concentrations of [F-18]DPA-714, a PET imaging marker of neuroinflammation, will be compared between study participants who have recently been hospitalized for acute myocardial infarction (AMI) and a control group undergoing elective percutaneous coronary interventions (PCI).

Measure: TPSO-PET measurement of neuroinflammation after acute myocardial infarction

Time: 2 years

Purpose: Diagnostic

Allocation: Non-Randomized

Single Group Assignment

There is one SNP


1 rs6971

English speaking with at least 8th grade education 4. High or mixed affinity binder for TSPO ligands based on genotyping for single nucleotide polymorphism (SNP) rs6971.

Diagnosis of dementia 12. Low affinity binder for TSPO ligands based on genotyping for SNP rs6971.

HPO Nodes