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Report for Clinical Trial NCT02527291

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Cytomegalovirus Reactivation in Non Immunocompromised Patients Undergoing Cardiac Surgery

We hypothesized that the stress of cardiac surgery and cardiopulmonary bypass can cause reactivation of a latent CMV infection and that reactivation might be more prevalent in patients with complicated post-operative course. The study aims are: - To study whether cardiac surgery is a trigger for latent CMV reactivation and to compare reactivation rate between sub groups of patient with complicated post-operative course and non complicated post operative course. - To study the relationship between expression IL28 SNP rs12979860 and the risk of CMV replication in the non immunocompromised patient undergoing cardiac surgery.

NCT02527291 Cardiac Surgery

1 Interventions

Name: Blood test

Description: Blood test for CMV PCR and IL28
Type: Other
Group Labels: 3

Control Group 1 Control Group 2 Study Group

Primary Outcomes

Measure: The cumulative of death, prolonged hospitalization, prolonged post-operative mechanical ventilation and prolonged use of vasopressors

Time: 12 months

Measure: CMV reactivation: viral load elevation comparing to the baseline level prior to surgery

Time: 12 months

Secondary Outcomes

Measure: The relationship between expression IL28 SNP rs12979860 and the risk of CMV replication in the non immunocompromised patient undergoing cardiac surgery.

Time: 12 months
Time Perspective: Prospective

Case Control

There is one SNP

SNPs

1 rs12979860

- To study the relationship between expression IL28 SNP rs12979860 and the risk of CMV replication in the non immunocompromised patient undergoing cardiac surgery.

The relationship between expression IL28 SNP rs12979860 and the risk of CMV replication in the non immunocompromised patient undergoing cardiac surgery.. null.


HPO Nodes