SNPMiner Trials by Shray Alag

SNPMiner SNPMiner Trials (Home Page)

Report for Clinical Trial NCT01015963

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

A Study of the Docetaxel Pharmacodynamics and Polymorphisms in ABCC2 and SLC01B3 in Caucasian and African-American Cancer Patients

This research trial studies deoxyribonucleic acid (DNA) in blood samples from Caucasian and African-American cancer patients who received docetaxel on clinical trial CLB-9871. Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about how docetaxel is used by the body.

NCT01015963 Bladder Cancer Breast Cancer Head and Neck Cancer Lung Cancer Unspecified Adult Solid Tumor, Protocol Specific
MeSH:Breast Neoplasms Lung Neoplasms Head and Neck Neoplasms Urinary Bladder Neoplasms
HPO:Bladder neoplasm Breast carcinoma Neoplasm of head and neck Neoplasm of the breast Neoplasm of the lung

1 Interventions

Name: laboratory biomarker analysis

Description: Perform DNA sample analysis
Type: Other
Group Labels: 1

Ancillary-correlative (DNA sample analysis)

Primary Outcomes

Measure: Incidence of ABBC2 polymorphism (rs12762549) and a SLC01B3 polymorphism (rs11045585) with docetaxel exposure

Time: Up to 2 years

Measure: Incidence of SLC01B3 polymorphism (rs11045585)

Time: Up to 2 years

Secondary Outcomes

Measure: Incidence of grade III/IV leukopenia/neutropenia (induced by docetaxel)

Time: Up to 2 years
Time Perspective: Retrospective

Case-Only

There are 2 SNPs

SNPs

1 rs11045585

Incidence of ABBC2 polymorphism (rs12762549) and a SLC01B3 polymorphism (rs11045585) with docetaxel exposure.

Incidence of SLC01B3 polymorphism (rs11045585).

2 rs12762549

Incidence of ABBC2 polymorphism (rs12762549) and a SLC01B3 polymorphism (rs11045585) with docetaxel exposure.


HPO Nodes

HPO:
HP:0009725: Bladder neoplasm
Genes 31
CTNNB1 AXIN2 HRAS PTEN SRC DLC1 PIK3CA FLCN AKT1 FGFR3 NTHL1 HRAS ATP7A NRAS AAGAB EP300 CCND1 BUB1 APC TP53 KRAS PIK3CA RNF43 RB1 PTPRJ DCC AKT1 COL14A1 BUB1B FGFR3 NTHL1
Protein Mutations 1
V617F
SNP 2
rs11045585 rs12762549
HP:0003002: Breast carcinoma
Genes 97
APC BRCA2 PPM1D AKT1 PALB2 IDH2 BRCA1 SLC22A18 BRCA1 SDHB XRCC3 STK11 PIK3CA PIK3CA TP53 STK11 RAD51D SDHD RNF43 AKT1 ATM ESR1 PTEN SMAD4 TP53 NTHL1 MRE11 CHEK2 PALB2 BRCA2 RAD51 BRCA1 AKT1 CHEK2 CHEK2 RAD51C RAD50 POLD1 CHEK2 ATR MSH2 PTEN TP53 SLC6A17 CDH1 COL14A1 POLE SEC23B TP53 BRCA1 KRAS RAD51 PTEN PALB2 TP53 OPCML PRKN USF3 NTHL1 SEC23B CASP8 RB1CC1 CTNNB1 AAGAB KRAS CDH1 NBN BRIP1 IDH1 MLH1 KLLN PIK3CA MSH6 APC PALLD HMMR WRN MDM2 BRIP1 BARD1 RAD54L RAD51C NQO2 CDKN2A TWIST1 MSH2 PIK3CA BARD1 FGFR2 SDHC AKT1 MLH1 PHB BRCA1 BRCA2 BRCA2 CDKN2A
Protein Mutations 73
A289T A864V C3435T D538G D769H D769N D769Y D988Y E380Q E542K E545K E709K E757A G309A G309E G598V G776C G776V H1047R I655V I767M L536H L536P L536Q L536R L755P L755S L786V L841V L858R L861Q L869R P125A P12A P13K P187S P535H P596L R108K R222C R572Y R678Q R831C R831H R849W R896C S310F S310Y S463P S653C S768I S8814A S9313A T47D T733I T790M T798I T798M T862I V244M V534E V600E V659E V697L V742I V769M V773M V774M V777L V842I Y537C Y537N Y537S
SNP 38
rs1011970 rs10407022 rs1045485 rs10941679 rs10995190 rs11045585 rs11133360 rs11249433 rs12762549 rs13281615 rs13387042 rs16942 rs1800566 rs2002555 rs2046210 rs2237060 rs2241193 rs2297480 rs236114 rs2380205 rs271924 rs2981582 rs3803662 rs3817198 rs4073 rs4646 rs4973768 rs614367 rs6504950 rs6971 rs704010 rs7333181 rs7349683 rs889312 rs909253 rs9344 rs9457827 rs999737
HP:0012288: Neoplasm of head and neck
Genes 25
APC KIT DLEC1 KIT STAT1 CTHRC1 HABP2 FOXE1 RAD21 MINPP1 FH SDHB WWOX PDGFRA RHBDF2 STK11 TGFBR2 ASCC1 RNF6 SDHA SDHC APC RHBDF2 RSPRY1 MSR1
Protein Mutations 2
E10A P13K
SNP 2
rs11045585 rs12762549
HP:0100013: Neoplasm of the breast
Genes 125
APC BRCA2 PPM1D AKT1 PALB2 IDH2 BRCA1 SLC22A18 BRCA1 SDHB XRCC3 STK11 PIK3CA TERT LMNA PIK3CA TP53 STK11 RAD51D SDHD RNF43 AKT1 ATM ESR1 FASLG APC PTEN MITF RASGRP1 CASP10 SMAD4 PRLR TP53 NTHL1 PTEN MRE11 BAP1 C11ORF95 CHEK2 PALB2 BRCA2 RAD51 BRCA1 RELA AKT1 CHEK2 CHEK2 RAD51C APC CDKN2A RAD50 PTEN GNAS POLD1 CHEK2 ATR MSH2 PTEN TP53 SLC6A17 CDH1 COL14A1 POLE PRKCD SEC23B TP53 BRCA1 KRAS RAD51 PTEN PALB2 TP53 OPCML PRKN USF3 NTHL1 SEC23B MGMT CASP8 RB1CC1 CTNNB1 AAGAB TERF2IP KRAS CDH1 NBN FAS BRIP1 IDH1 MLH1 KLLN PIK3CA MSH6 APC PALLD MC1R HMMR WRN MDM2 PTEN BRIP1 CDKN2B BARD1 RAD54L RAD51C POT1 NQO2 CDKN2A FAS TWIST1 MSH2 PIK3CA BARD1 FGFR2 CDK4 SDHC AKT1 MLH1 PHB BRCA1 BRCA2 BRCA2 CDKN2A ACD PRKAR1A
Protein Mutations 0
SNP 0
HP:0100526: Neoplasm of the lung
Genes 62
TP53 SLCO2A1 STAT6 WT1 BRAF HPGD TSC1 PRKN CYP2A6 PPP2R1B LMNA MUC5B PIK3CA DIS3L2 CASP8 STK11 H19 BRCA2 NOTCH3 WT1 SFTPA2 TSC2 FASLG BAP1 WRN ERCC6 MBTPS2 DICER1 C11ORF95 TRIM28 RB1 GPC3 RELA PERP SFTPC SLC22A18 PDGFRB ERBB2 TSC2 PTEN TRIP13 EWSR1 MAP3K8 TSC1 TRPV3 DICER1 TERT TRIM28 IRF1 REST TSC1 TP53 KEAP1 DICER1 AKT1 KRAS POU6F2 NAB2 TSC1 WT1 EGFR TSC2
Protein Mutations 52
C1156Y C797S D594G F1174C F1174V G1202R G1269A G12C G12D G469A G719A G719C G719S G776C G776V I10A L1196M L1198F L523S L755S L833F L8585R L858R L859R L861G L861Q L861R N375S P13K P4503A R776G R831C S1400A S1400C S1400D S1400E S1400F S1400G S1400I S1400K S1800A S1900A S1900C S1900D S768I T790M T81C T890M V600E V769L V777L V843I
SNP 6
rs1047768 rs10937405 rs11045585 rs12762549 rs4488809 rs751402