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Report for Clinical Trial NCT02543216

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Gene - Diet Interactions in Fatty Acid Desaturase 1 Gene (FADSDIET)

Interactions between genes and environment, are likely to be crucial in the development of the common diseases such as type 2 diabetes. It was recently shown that FADS1 and FADS 2 genotypes are the strongest genes in a genome-wide analysis regulating serum fatty acid profile.The aim of this study is to test if subjects with the CC and TT genotypes of the FADS1 gene (rs174547) respond differentially to a diet supplemented with linoleic acid (substrate for FADS). We hypothesize that subjects with the TT genotype with more active desaturases will be more sensitive to dietary modification leading to more robust differences in serum FA profile, tissue inflammation and serum lipids.

NCT02543216 Fatty Acid

1 Interventions

Name: Sunflower oil

Description: Study diets were isocaloric following the habitual diet of the participants with a supplement of 30-50 ml (25-45 g) sunflower oil daily depending on body weight. Thus, approximately 16-28 g (6 E%) LA were provided daily on top of the average intake of approximately 10-12 g (4.5 E%).
Type: Dietary Supplement
Group Labels: 2

CC genotype TT genotype

Primary Outcomes

Measure: Fatty acid profile of serum lipid fractions

Time: 4 weeks

Secondary Outcomes

Measure: Serum lipids an lipoproteins

Time: 4 weeks

Measure: Adipose tissue biopsies

Time: 4 weeks

Measure: white blood cell samples

Time: 4 weeks
Purpose: Prevention

Allocation: Non-Randomized

Parallel Assignment

There is one SNP

SNPs

1 rs174547

It was recently shown that FADS1 and FADS 2 genotypes are the strongest genes in a genome-wide analysis regulating serum fatty acid profile.The aim of this study is to test if subjects with the CC and TT genotypes of the FADS1 gene (rs174547) respond differentially to a diet supplemented with linoleic acid (substrate for FADS).

Inclusion Criteria: Participant of Metabolic syndrome in men (METSIM) cohort BMI 20-30 kg/m2 Healthy CC/TT genotype (rs 174547) Exclusion Criteria: Type 2 diabetes Other chronic disease Inclusion Criteria: Participant of Metabolic syndrome in men (METSIM) cohort BMI 20-30 kg/m2 Healthy CC/TT genotype (rs 174547) Exclusion Criteria: Type 2 diabetes Other chronic disease Fatty Acid Lean and overweight subjects (BMI >20kg/m2 <29kg/m2 ) with CC and TT genotypes of FADS1 polymorphism (rs174547) were recruited from the METSIM study (METabolic Syndrome in Men, currently >10000 men included from the population living in Kuopio).


HPO Nodes