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Report for Clinical Trial NCT03336463
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
Prediction of Recurrent Pregnancy Loss by a New Thrombophilia Based Genetic Risk Score
Recurrent pregnancy loss (RPL) is a clinical problem affecting 1-5% of couples of reproductive age. The contribution of thrombophilia to RPL is disputed. This controversy is partly due to low sensitivity of the genetic variants currently used to evaluate hereditary thrombophilia: the Leiden mutation (identified as rs6025) in the coagulation factor 5 (F5L) gene and mutation G20210A (identified as rs1799963) in the prothrombin (PT) gene. Our objective was to determine whether a wider algorithm that includes clinic and genetic variants associated with thrombophilia could be more useful in the prediction for RPL than FVL and PT alone.
NCT03336463 Miscarriage, Recurrent MeSH:Abortion, Spontaneous Abortion, Habitual Thrombophilia
HPO:Hypercoagulability Spontaneous abortion
Primary Outcomes
Description: Repeated clinical pregnancy loss and/or foetal death (≥ 2 consecutive or ≥ 3 non-consecutive) before the 20th weeks of pregnancy
Measure: Recurrent Pregnancy Loss Time: 20 weeks
Description: Pregnancy with life-birth
Measure: Pregnancy at term Time: 20 weeks
Time Perspective: Retrospective
Primary Outcomes
Description: Repeated clinical pregnancy loss and/or foetal death (≥ 2 consecutive or ≥ 3 non-consecutive) before the 20th weeks of pregnancy
Measure: Recurrent Pregnancy Loss Time: 20 weeksDescription: Pregnancy with life-birth
Measure: Pregnancy at term Time: 20 weeksCase-Control
There are 2 SNPs
SNPs
1 rs1799963
This controversy is partly due to low sensitivity of the genetic variants currently used to evaluate hereditary thrombophilia: the Leiden mutation (identified as rs6025) in the coagulation factor 5 (F5L) gene and mutation G20210A (identified as rs1799963) in the prothrombin (PT) gene.
2 rs6025
This controversy is partly due to low sensitivity of the genetic variants currently used to evaluate hereditary thrombophilia: the Leiden mutation (identified as rs6025) in the coagulation factor 5 (F5L) gene and mutation G20210A (identified as rs1799963) in the prothrombin (PT) gene.