SNPMiner Trials by Shray Alag


SNPMiner SNPMiner Trials (Home Page)


Report for Clinical Trial NCT03608878

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Randomized, Controlled, Open Label, Clinical Trial for Adagloxad Simolenin/OBI-821 in Combination With TACE Therapy in Hepatocellular Carcinoma Patients With GALNT14-rs9679162-non-TT Genotype

TACE against HCC is the standard of care for BCLC stage B patients. In this exploratory study, the investigators assess the efficacy of TACE with or without adagloxad simolenin/OBI-821 treatment in GALNT14 "non-TT" HCC population.

NCT03608878 Hepatocellular Carcinoma
MeSH:Carcinoma Carcinoma, Hepatocellular
HPO:Carcinoma Hepatocellular carcinoma

2 Interventions

Name: adagloxad simolenin/OBI-821

Description: Adagloxad simolenin (OBI-822) is a glyco-conjugated protein comprised of a carbohydrate tumor antigen. Globo H allyl glycoside is covalently linked to a carrier protein KLH, presented in a dominant trimer form with molecular weight between 1200-1395 kDa., to form Adagloxad simolenin (OBI-822) (Globo H-KLH) OBI-821 is a saponin based adjuvant structurally similar to descriptions found in the literature for another adjuvant, QS-21. Adagloxad simolenin will be mixed with OBI-821 before administration.
Type: Biological
Group Labels: 1

adagloxad simolenin arm

Name: TACE

Description: Transarterial chemoembolization
Type: Procedure
Group Labels: 2

TACE alone arm adagloxad simolenin arm


Primary Outcomes

Description: time-to-intrahepatic total tumor volume progression

Measure: time-to-ITTVP

Time: From enrollment till 36 months of follow-up.

Purpose: Treatment

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 rs9679162

5. Child-Pugh functional class A or B. 6. GALNT14- rs9679162 "non TT" genotype 7.



HPO Nodes


HPO: