SNPMiner Trials by Shray Alag


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Report for Clinical Trial NCT04251221

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Measuring the Neuroimmune Response to Alcohol

This study uses positron emission tomography imaging of the 18-kDa translocator protein to measure the brain's immune response to alcohol.

NCT04251221 Alcohol Drinking Alcohol Use Disorder
MeSH:Alcoholism Alcohol Drinking

1 Interventions

Name: Oral Alcohol Challenge

Description: Subjects will drink an alcohol dose designed to achieve a BAL of 0.08
Type: Drug
Group Labels: 2

Alcohol Use Disorder Social Drinkers


Primary Outcomes

Description: This is the percent change in [11C]PBR28 distribution volume post-alcohol relative to baseline. As a percent change, it could range from -10% to 200%.

Measure: Neuroimmune Response to Alcohol

Time: Measured 1-4 hours after oral alcohol challenge ends - Will require ~120 minutes

Description: This is the percent change in scores across the cogstate battery. These values could realistically vary much more widely, from -1000% to 1000% (although this extent is not expected).

Measure: Working Memory

Time: The morning following alcohol challenge - Will require ~30 minutes

Description: The percent change score in performance on the probabilistic response task. These values could realistically vary much more widely, from -300% to 300% (although this extent is not expected).

Measure: Anhedonia

Time: The morning following alcohol challenge - Will require ~30 minutes

Purpose: Basic Science

Allocation: Non-Randomized

Parallel Assignment


There is one SNP

SNPs


1 rs6971

Specifically, we will exclude subjects who a) have a history of perceptual distortions, seizures, delirium, or hallucinations upon withdrawal or b) have a score of > 8 on the Clinical Institute Withdrawal Assessment scale at intake - Individuals who are classified as "low binders" for the rs6971 polymorphism (<10% of the population).



HPO Nodes