This study uses positron emission tomography imaging of the 18-kDa translocator protein to measure the brain's immune response to alcohol.
Name: Oral Alcohol Challenge
Description: This is the percent change in [11C]PBR28 distribution volume post-alcohol relative to baseline. As a percent change, it could range from -10% to 200%.Measure: Neuroimmune Response to Alcohol Time: Measured 1-4 hours after oral alcohol challenge ends - Will require ~120 minutes
Description: This is the percent change in scores across the cogstate battery. These values could realistically vary much more widely, from -1000% to 1000% (although this extent is not expected).Measure: Working Memory Time: The morning following alcohol challenge - Will require ~30 minutes
Description: The percent change score in performance on the probabilistic response task. These values could realistically vary much more widely, from -300% to 300% (although this extent is not expected).Measure: Anhedonia Time: The morning following alcohol challenge - Will require ~30 minutes
There is one SNP
Specifically, we will exclude subjects who a) have a history of perceptual distortions, seizures, delirium, or hallucinations upon withdrawal or b) have a score of > 8 on the Clinical Institute Withdrawal Assessment scale at intake - Individuals who are classified as "low binders" for the rs6971 polymorphism (<10% of the population).