Correlated Drug Terms (0)

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	Name (Synonyms)	Correlation

Correlated MeSH Terms (1)

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	Name (Synonyms)	Correlation
D013315	Stress, Psychological NIH	0.21

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: Psychological distress will be assessed by aggregating 3 measures: PROMIS anxiety and PROMIS depression, and the NIH Toolbox Perceived Stress Scale. Averages will be z-scored with a mean of 0 and a standard deviation 1. Higher scores indicate increased psychological distress.

Measure: Change from baseline on an aggregate measure of Psychological distress that averages the Patient-Reported Outcomes Measurement Information System (PROMIS) Anxiety and Depressive Measures and the NIH Perceived Stress Scale

Time: baseline, after weeks 1, 2, and 3 of the intervention, 4 weeks (post intervention), 16 weeks (3 months post-intervention)

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Secondary Outcomes

Description: A measure of acting with mindful awareness. The total possible range in scores is 8-40, with higher scores indicating greater levels of this facet of mindfulness.

Measure: Change from baseline on the Five Facet Mindfulness Questionnaire Act with Awareness subscale

Time: baseline, after weeks 1, 2, and 3 of the intervention, 4 weeks (post intervention), 16 weeks (3 months post-intervention)

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Description: Psychological distancing (i.e., defusion) will be assessed with the 10-item Drexel Defusion Scale (DDS). The total possible range in scores is 0-50, with higher scores indicating greater levels of psychological distancing.

Measure: Change from baseline on the Drexel Defusion Scale (DDS)

Time: baseline, after weeks 1, 2, and 3 of the intervention, 4 weeks (post intervention), 16 weeks (3 months post-intervention)

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Description: The Meaning in Life Questionnaire Presence subscale will be used to measure perceptions of meaning and purpose in life. The total possible range in scores is 5 - 35 with higher scores indicating greater levels of meaning.

Measure: Change from baseline on the Meaning in Life Questionnaire

Time: baseline, after weeks 1, 2, and 3 of the intervention, 4 weeks (post intervention), 16 weeks (3 months post-intervention)

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Description: A measure of loneliness (i.e, lack of social connectedness). The total possible range in scores is 1-5, representing the average across all items; higher scores indicate greater levels of loneliness.

Measure: Change from baseline on the NIH Toolbox Loneliness scale

Time: baseline, after weeks 1, 2, and 3 of the intervention, 4 weeks (post intervention), 16 weeks (3 months post-intervention)

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Description: The Conway COVID Questionnaire is a new, 16-tem measure of coronavirus related distress and related experiences. The perceived coronavirus threat, coronavirus impacts questionnaire, and coronavirus experiences subscales will be summed. The total possible range in scores is 7 - 112 with higher scores representing greater perceived threat.

Measure: Change from baseline on the Conway COVID Questionnaire

Time: baseline, 4 weeks (post intervention), 16 weeks (3 months post-intervention)

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Description: The Self-Compassion Scale Short Form will be used to measure self-compassion. The total possible range in scores is 12-60, with higher scores indicating greater levels of self-compassion.

Measure: Change from baseline on the Self-Compassion Scale Short Form

Time: baseline, 4 weeks (post intervention), 16 weeks (3 months post-intervention)

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Description: Negative ruminative thinking will be measured with the Perseverative Thought Questionnaire. The total possible range in scores is 0-60, with higher scores indicating greater levels negative ruminative thinking.

Measure: Change from baseline on the Perseverative Thought Questionnaire

Time: baseline, 4 weeks (post intervention), 16 weeks (3 months post-intervention)

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Description: Well-being with be measured using the WHO-5. The total possible range in scores is 0-25, with higher scores indicating greater levels of well-being.

Measure: Change from baseline on the World Health Organization 5-item (WHO-5) well-being scale

Time: baseline, 4 weeks (post intervention), 16 weeks (3 months post-intervention)

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Description: The Neutral Face Rating task is a novel measure of prosocial construal (average likability ratings) and race bias (average liking of white faces minus the average liking of black faces). Total score for both prosocial construal and bias range from 1 to 7, with higher scores representing greater prosocial construal and bias favoring white faces (negative scores on the bias measure indicate bias for liking black faces more than white faces).

Measure: Change from baseline on the Neutral Face Rating task

Time: baseline, 4 weeks (post intervention), 16 weeks (3 months post-intervention)

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Description: A measure of fixed versus incremental mindset regarding well-being. The average across items for a possible range in scores from 1-6 will be measured, with higher scores indicating greater levels of incremental views on well-being (i.e., it can be learned).

Measure: Change from baseline on the Growth Mindset Scale for Well-Being

Time: baseline, 4 weeks (post intervention)

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Other Outcomes

Description: 4-tems following each app-based practice for treatment participants that ask about perceive quality of the practice, (1 poor, 9 very good), and mood (1 poor, 5 good).

Measure: Slope across time on Practice quality and mood items

Time: Every other day when participant completes a practice (up to 4 weeks)

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Description: A measure of working alliance in a digital environment that will be averaged across all items for a score range from 1 to 7, with higher scores reflecting higher levels of alliance.

Measure: Digital working alliance

Time: After weeks 1, 2, and 3 during the intervention, 4 weeks (post intervention), 16 weeks (3 months post-intervention) - Intervention group only

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