Correlated Drug Terms (2)

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	Name (Synonyms)	Correlation
drug2998	sertraline Wiki	1.00
drug1822	Placebo Wiki	0.06

Correlated MeSH Terms (2)

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	Name (Synonyms)	Correlation
D040921	Stress Disorders, Traumatic NIH	0.22
D013313	Stress Disorders, Post-Traumatic NIH	0.20

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: The CAPS-5 is the "gold standard" clinical interview for assessing PTSD. This measure will be used to characterize the sample regarding PTSD diagnosis and as a measure of PTSD severity. Each of the 20 symptoms of PTSD included in DSM-5 is rated on a 5-point scale ranging from 0-4, with a 0 or 1 indicating that the symptom is absent or subthreshold and a score of 2-4 indicating that a symptom has reached the threshold to be included as a symptom and ranges in severity from moderate to extreme. The total range of the CAPS-5 is 0-80.

Measure: Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) Change

Time: Administered at screening session 1, and weeks 0, 2, 6, and 14

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Secondary Outcomes

Description: The QIDS-SR will be used to measure the severity of depressive symptoms. The QIDS provides equivalent weightings (0-3) for each symptom item, gives clearly stated anchors that estimate the frequency and severity of symptoms, and includes all items required to diagnose a major depressive episode.

Measure: Quick Inventory of Depressive Symptomatology- Self Report (QIDS-SR) Change

Time: Administered at screening session 1, and weeks 0, 2, 4, 6, 8, 10, 12, and 14

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Description: The HAM-D is the most widely used clinician-administered scale for assessing severity of depression symptoms. The 6-item unidimensional core Melancholia subscale of the HAM-D will be used as the primary depression outcome variable.

Measure: Hamilton Depression Rating Scale (HAM-D) Change

Time: Administered at weeks 0, 2, 6 and 14

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Description: DASS-21 is a 21-item measure that assesses the severity of a range of symptoms common to depression, anxiety, and stress. The total score can be used as a measure of general distress or depression, anxiety, and stress subscales can be scored separately.

Measure: Depression Anxiety Stress Scales (DASS-21) Change

Time: Administered at screening session 1, and weeks 0, 2, 6, and 14

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Description: The PCL-5 is a 20-item measure that assesses DSM-5 symptoms of PTSD. Participants will rate how much they experienced each symptom on a 5-point Likert-type scale (0 = "not at all" to 4 = "extremely") during the past week (total range=0-80). The PCL-5 will be anchored to participants' worst traumatic event. In addition to the administration of these measures during the four assessment sessions, the PCL-5 will also be administered bi-weekly at each psychiatrist check-in visit.

Measure: PTSD Checklist for DSM-5 (PCL-5) Change

Time: Administered at screening session 1, and weeks 0, 2, 4, 6, 8, 10, 12, and 14

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Description: The PANAS consists of two, 10-item mood scales that measure positive (e.g., 'enthusiastic') and negative (e.g., 'upset') affect separately.

Measure: The Positive and Negative Affect Schedule (PANAS) Change

Time: Administered at screening session 1, and weeks 0, 2, 6, and 14

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Description: SCL-90-R measures the following nine primary psychiatric symptom dimensions: somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism. The Global Severity Index (GSI) is the average rating given to all 90 items and provides a measure of general psychopathology.

Measure: Symptom Checklist (SCL-90-R) Change

Time: Administered at screening session 1, and weeks 0, 2, 6, and 14

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