Name (Synonyms) | Correlation | |
---|---|---|
drug2515 | Thrombomodulin Modified Thrombin Generation Assay (TGA-TM) Wiki | 1.00 |
drug576 | Clazakizumab Wiki | 0.45 |
drug1645 | Normal saline Wiki | 0.45 |
Name (Synonyms) | Correlation | |
---|---|---|
D004211 | Disseminated Intravascular Coagulation NIH | 0.50 |
D020141 | Hemostatic Disorders NIH | 0.30 |
D001778 | Blood Coagulation Disorders NIH | 0.30 |
D016638 | Critical Illness NIH | 0.14 |
D014777 | Virus Diseases NIH | 0.12 |
D007239 | Infection NIH | 0.06 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0005521 | Disseminated intravascular coagulation HPO | 0.50 |
HP:0001928 | Abnormality of coagulation HPO | 0.30 |
There is one clinical trial.
Inflammation and abnormalities in laboratory coagulation tests are inseparably tied. For example, coagulation abnormalities are nearly universal in septic patients. Coagulation disorders have also been reported in many patients with severe courses of Coronavirus disease 2019 (Covid-19). But it is difficult to assess these changes. Global coagulation tests have been shown to incorrectly assess in vivo coagulation in patients admitted to intensive care units. But other tests are available. Thrombin generation assay (TGA) is a laboratory test which allows the assessment of an individual's potential to generate thrombin. But also in conventional TGA the protein C system is hardly activated because of the absence of endothelial cells (containing natural thrombomodulin) in the plasma sample. Therefore the investigators add recombinant human thrombomodulin to a conventional TGA. Thereby the investigators hope to be able to depict in vivo coagulation more closely than global coagulation tests do.
Description: nM;
Measure: ETP (AUC) without rhThrombomodulin (rhTM) Time: 6 monthsDescription: nM;
Measure: ETP (AUC) with rhThrombomodulin (rhTM) Time: 6 monthsDescription: Ratio of endogenous thrombin potential (ETP) with rhTM to ETP without rhTM
Measure: ETP-ratio Time: 6 monthsDescription: Comparison of ETP-ratios from ICU patients and ETP-ratios from citrated plasma samples from healthy donors
Measure: ETP-Normalisation Time: 6 months