CovidResearchTrials by Shray Alag


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GO2 PEEP MOUTHPIECEWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (0)


Name (Synonyms) Correlation

Correlated MeSH Terms (4)


Name (Synonyms) Correlation
D003141 Communicable Diseases NIH 0.09
D007239 Infection NIH 0.06
D045169 Severe Acute Respiratory Syndrome NIH 0.05
D018352 Coronavirus Infections NIH 0.04

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 GO2 PEEP Study: The Use of a Bidirectional Oxygenation Valve in the Management of Pulmonary Complications of COVID-19

The objective of this study is to determine the safety, feasibility and efficacy of a bidirectional oxygenation Positive End Expiratory Pressure (PEEP) mouthpiece in coronavirus disease 2019 (COVID-19) patients requiring supplemental oxygen by non-rebreather mask.

NCT04331366 COVID-19 Device: GO2 PEEP MOUTHPIECE

Primary Outcomes

Description: Pulse oximetry is a way to assess whether or not a patient needs help breathing. Oxygen saturation levels for healthy individuals are 95% and above.

Measure: Change in Oxygen Saturation by Pulse Oximetry

Time: Baseline, Minutes 5, 10, 15, 30 (15 minutes after treatment ends)

Secondary Outcomes

Description: The number of breaths per minute will be assessed before treatment, during treatment, and 15 minutes after the end of treatment.

Measure: Change in Respiratory Rate

Time: Baseline, Minutes 5, 10, 15, 30 (15 minutes after treatment ends)

Description: Heart rate, in beats per minute, will be assessed before treatment, during treatment, and 15 minutes after the end of treatment.

Measure: Change in Heart Rate

Time: Baseline, Minutes 5, 10, 15, 30 (15 minutes after treatment ends)

Description: Systolic and diastolic blood pressure will be assessed before treatment, during treatment, and 15 minutes after the end of treatment.

Measure: Change in Blood Pressure

Time: Baseline, Minutes 5, 10, 15, 30 (15 minutes after treatment ends)

Description: The participant will be observed for stridor, grunting, nasal flaring, or accessory muscle use. The presence of any of these indicates that increased effort is required for breathing.

Measure: Change in Subjective Work of Breathing

Time: Baseline, Minutes 5, 10, 15, 30 (15 minutes after treatment ends)

Description: PaO2 assesses the effects of respiratory distress by measuring the pressure of oxygen dissolved in arterial blood. Normal values are greater than 80 millimeters of mercury (mmHg).

Measure: Change in Partial Pressure of Oxygen (PaO2)

Time: Baseline, Minutes 5, 10, 15, 30 (15 minutes after treatment ends)

Description: PaCO2 assesses respiratory state by measuring the pressure of carbon dioxide in blood. and how well carbon dioxide is able to move out of the body. Normal values are between 35 and 45 mmHg. Values below 35 mmHg indicate too little carbon dioxide in blood while values above 45 mmHg mean there is an excess of carbon dioxide.

Measure: Change in Partial Pressure of Carbon Dioxide (PaCO2)

Time: Baseline, Minutes 5, 10, 15, 30 (15 minutes after treatment ends)

Description: The pH measures hydrogen ions (H+) in blood. The pH of blood is usually between 7.35 and 7.45. A pH of less than 7.35 means the patient is acidotic while values greater than 7.45 mean the patient is alkalotic.

Measure: Change in pH

Time: Baseline, Minutes 5, 10, 15, 30 (15 minutes after treatment ends)

Description: HCO3 is the calculated concentration of bicarbonate in arterial blood. Bicarbonate prevents the pH of blood from becoming too acidic or too basic. Normal values are between 22-26 milliequivalent per liter (mEq/L).

Measure: Change in Bicarbonate (HCO3)

Time: Baseline, Minutes 5, 10, 15, 30 (15 minutes after treatment ends)

Description: Oxygen saturation measured by the arterial blood gas test, shows how much oxygen is being carried by hemoglobin in the red blood cells. Normal values are between 95% and 100%

Measure: Change in Oxygen Saturation (O2Sat) by Arterial Blood Gas Test

Time: Baseline, Minutes 5, 10, 15, 30 (15 minutes after treatment ends)


No related HPO nodes (Using clinical trials)