Name (Synonyms) | Correlation | |
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drug406 | Bromhexine Hydrochloride Wiki | 1.00 |
drug1103 | Hydroxychloroquine Sulfate Wiki | 0.28 |
Name (Synonyms) | Correlation | |
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D003141 | Communicable Diseases NIH | 0.09 |
D007239 | Infection NIH | 0.06 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
This is a three-arm randomized trial comparing the efficacy of single agent hydroxychloroquine to the combination of hydroxychloroquine and azithromycin, and to a delayed hydroxychloroquine regimen, which will serve as a contemporaneous Day 1-6 supportive care control, in eliminating detectable SARS-CoV-2 on day 6 following the initiation of treatment in order to determine which regimen is more effective.
Description: Will be assessed at day six compared to baseline between hydroxychloroquine sulfate alone and hydroxychloroquine sulfate plus azithromycin to treat COVID-19.
Measure: Changes in patients viral load Time: Baseline, day 3 and day 6Description: A second concurrent comparison will evaluate change in viral load at day 6 between hydroxychloroquine sulfate alone and supportive care.
Measure: Second evaluation of changes in patients viral load Time: Day 6Description: Time to resolution of symptoms
Measure: Symptom questionnaire Time: up to 6 monthsDescription: Change in the fever curve resulting in shorter time to afebrile for 48 hours
Measure: Fever assessment Time: up to 10 daysDescription: Body temperature will be measured in degrees Fahrenheit using an automated thermometer which will be provided to the patient 4 times per day.
Measure: Vital Signs - Body Temperature Time: up to 10 daysDescription: Time to discharge (If hospitalized)
Measure: Discharge Time: up to 6 monthsDescription: Time to recovery (back to school, work, etc)
Measure: Recovery Time: up to 6 monthsDescription: As measured by standard metrics
Measure: Assessment of agent toxicity Time: up to 10 daysDescription: Collection of Oropharynx swabs for viral load and microbiome analysis
Measure: Oropharynx swab sample collections Time: up to 10 daysDescription: Collection of blood for viral load and microbiome analysis
Measure: Blood Sample collections Time: up to 10 daysDescription: Decrease in virus shedding in nasopharyngeal secretions such as Ferritin, D-dimer, CRP, Troponin and LDH
Measure: Viral shedding assessment - nasopharyngeal secretions Time: up to 10 daysDescription: Decrease in virus shedding in serology such as Ferritin, D-dimer, CRP, Troponin and LDH
Measure: Viral shedding assessment - serology Time: up to 10 daysDescription: Measurement of cytokines in blood
Measure: Cytokines in blood Time: up to 10 days