CovidResearchTrials by Shray Alag


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Olfactory retrainingWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug1569 Nasal Irrigation Wiki 1.00
drug3002 smell household Items Wiki 1.00
drug2792 corticosteroid nasal irrigation Wiki 1.00

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D000857 Olfaction Disorders NIH 0.29

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0000458 Anosmia HPO 0.29

There is one clinical trial.

Clinical Trials


1 Olfactory Retraining Therapy and Budesonide Nasal Rinse for Anosmia Treatment in Patients Post-CoVID 19. A Randomized Controlled Trial

The study will be a randomized controlled trial, involving patients with hyposmia/anosmia of onset immediately after an upper respiratory viral illness, assigned to three distinct study arms. Nasal irrigations will be prescribed to all three groups (BID). In addition, one arm will receive a paper hand-out about post-viral anosmia with instructions to smell common household items (current care) and act as a control group. The second group will receive an essential oil retraining kit, whereas the third group will receive the same olfactory training kit and a prescription to use budesonide with the nasal irrigations. Olfactory scores will be tested at the enrollment, 3 months and at 6 months.

NCT04374474 Olfactory Disorder Other: Olfactory retraining Drug: corticosteroid nasal irrigation Other: smell household Items Other: Nasal Irrigation
MeSH:Olfaction Disorders
HPO:Anosmia

Primary Outcomes

Description: Score from the Snap and Sniff Olfactory Test results

Measure: Change from Baseline Snap and Sniff Threshold Test at 3 months

Time: 3 months

Description: Score from the Smell Identification test results.

Measure: Change from baseline Smell Identification Test (SIT) at 3 months

Time: 3 months

Description: Score from the Snap and Sniff Olfactory Test results

Measure: Change from Baseline Snap and Sniff Threshold Test at 6 months

Time: 6 months

Description: Score from the Smell Identification test results.

Measure: Change from baseline Smell Identification Test (SIT) at 6 months

Time: 6 months

Secondary Outcomes

Description: Scores from the short version of the Questionnaire of Olfactory Disorders Negative Statements (QOD-NS)

Measure: Change from baseline QOD-NS at 3 months

Time: 3 months

Description: Short Form 36 Health Survey scores

Measure: Change from baseline SF-36 health survey at 3 months

Time: 3 months

Description: Scores from the short version of the Questionnaire of Olfactory Disorders Negative Statements (QOD-NS)

Measure: Change from baseline QOD-NS at 6 months

Time: 6 months

Description: Short Form 36 Health Survey scores

Measure: Change from baseline SF-36 health survey at 6 months

Time: 6 months

Description: Adherence comparison between participants post-CoVID 19 and patients post other viral infections.

Measure: Adherence to the Study Protocol

Time: 6 months

Description: Compare the rate of recovery between post-COVID 19 patients and patients post other viral infections.

Measure: Recovery

Time: 6 months


Related HPO nodes (Using clinical trials)