Name (Synonyms) | Correlation | |
---|---|---|
drug2490 | The demographic, clinical, laboratory, and instrumental data Wiki | 0.71 |
drug232 | Asthma reliever therapies Wiki | 0.71 |
drug796 | Dupilumab (SAR231893/REGN668) Wiki | 0.71 |
drug519 | Cannabidiol Wiki | 0.71 |
drug231 | Asthma controller therapies (incl. prednisone/prednisolone) Wiki | 0.71 |
drug77 | ARBOX Wiki | 0.71 |
There are 2 clinical trials
There is an urgent need to evaluate interventions that could be effective against the infection with SARS-CoV 2. Tannins based wood extracts are an inexpensive and safe product with protective effect in both bacterial and viral infections likely due to its anti- inflammatory, anti-oxidative effects and their modulation of the intestinal microbiota. This randomized controlled trial seeks to evaluate the efficacy of the tannins based dietary supplement ARBOX in positive COVID-19 patients.
Description: defined as the time from first dose of polyphenol extract to hospital discharge
Measure: Time to hospital discharge Time: Throughout the Study (Day 0 to Day 28)Description: proportion
Measure: 28-day all-cause mortality Time: Throughout the Study (Day 0 to Day 28)Description: proportion
Measure: invasive ventilation on day 28 Time: Throughout the Study (Day 0 to Day 28)Description: mean difference
Measure: Difference in Pro and antiinflammatory citoquine levels Time: day 1-14Description: proportion
Measure: Negativization of COVID-PCR at day 14 Time: day 14The aim of this work is to conduct a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of cannabidiol (CBD - 300 mg a day) in patients infected with SARS-CoV-2. The specific objectives are to assess whether, in patients with mild and moderate forms of SARS-CoV-2, daily use of CBD 300 mg for fourteen days is capable of: i) decrease viral load; ii) modify inflammatory parameters, such as cytokines, measured from serum; iii) reduce clinical and emotional symptoms through daily clinical evaluation; iv) improve sleep; v) reduce hospitalization and worsen the severity of the disease; v) Monitor the possible adverse effects of CBD use in these patients.
Description: Mean reduction in viral load (reduction of ≥1 log10) over time during the study period
Measure: Reduction in viral load Time: Up to 28 daysDescription: Clinical CoVid19 symptoms improvement
Measure: Number of participants with negative Clinical CoVid19 symptoms as assessed by CTCAE v5.0 Time: Up to 28 daysDescription: Immune reaction
Measure: Change in proinflammatory cytokine concentration Time: Up to 28 daysDescription: A qualitative CT analysis of parenchymal lung damage induced by COVID-19
Measure: Describe the parenchymal lung damage induced by COVID-19 through a qualitative analysis with chest CT Time: 14 daysDescription: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
Measure: Number of participants with treatment-related adverse events as assessed by CTCAE v5.0 Time: Up to 28 daysDescription: Time to clinical improvement
Measure: Time to clinical improvement with CTCAE v5.0 CoVid19 symptoms to 0 Time: Up to 28 daysDescription: CoVid severity worsening
Measure: Number of participants that need hospitalisation Time: Up to 28 daysDescription: Mortality
Measure: 28-day mortality Time: Up to 28 daysDescription: Time to negative saliva
Measure: Time to negative saliva 2019-n-CoV RT-PCR Time: Up to 28 days