CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


PLACEBOWiki

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Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (6)


Name (Synonyms) Correlation
drug2490 The demographic, clinical, laboratory, and instrumental data Wiki 0.71
drug232 Asthma reliever therapies Wiki 0.71
drug796 Dupilumab (SAR231893/REGN668) Wiki 0.71
drug519 Cannabidiol Wiki 0.71
drug231 Asthma controller therapies (incl. prednisone/prednisolone) Wiki 0.71
drug77 ARBOX Wiki 0.71

Correlated MeSH Terms (4)


Name (Synonyms) Correlation
D001249 Asthma NIH 0.35
D007239 Infection NIH 0.04
D045169 Severe Acute Respiratory Syndrome NIH 0.04
D018352 Coronavirus Infections NIH 0.03

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0002099 Asthma HPO 0.35

There are 2 clinical trials

Clinical Trials


1 Efficacy of Tannin Specific Natural Extract for Coronavirus Disease (COVID-19): Randomized Controlled Trial

There is an urgent need to evaluate interventions that could be effective against the infection with SARS-CoV 2. Tannins based wood extracts are an inexpensive and safe product with protective effect in both bacterial and viral infections likely due to its anti- inflammatory, anti-oxidative effects and their modulation of the intestinal microbiota. This randomized controlled trial seeks to evaluate the efficacy of the tannins based dietary supplement ARBOX in positive COVID-19 patients.

NCT04403646 COVID-19 SARS-CoV 2 Coronavirus Infection Dietary Supplement: ARBOX Other: PLACEBO
MeSH:Infection Coronavirus Infections Severe Acute Respiratory Syndrome

Primary Outcomes

Description: defined as the time from first dose of polyphenol extract to hospital discharge

Measure: Time to hospital discharge

Time: Throughout the Study (Day 0 to Day 28)

Secondary Outcomes

Description: proportion

Measure: 28-day all-cause mortality

Time: Throughout the Study (Day 0 to Day 28)

Description: proportion

Measure: invasive ventilation on day 28

Time: Throughout the Study (Day 0 to Day 28)

Description: mean difference

Measure: Difference in Pro and antiinflammatory citoquine levels

Time: day 1-14

Measure: Difference in fecal intestinal microbiota composition

Time: day 1-14

Description: proportion

Measure: Negativization of COVID-PCR at day 14

Time: day 14

2 Cannabidiol (CBD) in Patients With Mild to Moderate Symptoms of Coronavirus 2019: A Randomized, Double-blind, Placebo-controlled Clinical Trial

The aim of this work is to conduct a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of cannabidiol (CBD - 300 mg a day) in patients infected with SARS-CoV-2. The specific objectives are to assess whether, in patients with mild and moderate forms of SARS-CoV-2, daily use of CBD 300 mg for fourteen days is capable of: i) decrease viral load; ii) modify inflammatory parameters, such as cytokines, measured from serum; iii) reduce clinical and emotional symptoms through daily clinical evaluation; iv) improve sleep; v) reduce hospitalization and worsen the severity of the disease; v) Monitor the possible adverse effects of CBD use in these patients.

NCT04467918 SARS-CoV2 Drug: Cannabidiol Other: PLACEBO

Primary Outcomes

Description: Mean reduction in viral load (reduction of ≥1 log10) over time during the study period

Measure: Reduction in viral load

Time: Up to 28 days

Secondary Outcomes

Description: Clinical CoVid19 symptoms improvement

Measure: Number of participants with negative Clinical CoVid19 symptoms as assessed by CTCAE v5.0

Time: Up to 28 days

Description: Immune reaction

Measure: Change in proinflammatory cytokine concentration

Time: Up to 28 days

Description: A qualitative CT analysis of parenchymal lung damage induced by COVID-19

Measure: Describe the parenchymal lung damage induced by COVID-19 through a qualitative analysis with chest CT

Time: 14 days

Description: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]

Measure: Number of participants with treatment-related adverse events as assessed by CTCAE v5.0

Time: Up to 28 days

Description: Time to clinical improvement

Measure: Time to clinical improvement with CTCAE v5.0 CoVid19 symptoms to 0

Time: Up to 28 days

Description: CoVid severity worsening

Measure: Number of participants that need hospitalisation

Time: Up to 28 days

Description: Mortality

Measure: 28-day mortality

Time: Up to 28 days

Description: Time to negative saliva

Measure: Time to negative saliva 2019-n-CoV RT-PCR

Time: Up to 28 days


No related HPO nodes (Using clinical trials)