Name (Synonyms) | Correlation | |
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D045169 | Severe Acute Respiratory Syndrome NIH | 0.05 |
D018352 | Coronavirus Infections NIH | 0.04 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
COVID-19 patients with a severely symptomatic progression with development of an Acute respiratory distress syndrome (ARDS) due to SARS-CoV-2 need prolonged intensive care treatment involving pharmacological immobilization, sedation and mechanical ventilation, leaving them at a very high risk for developing Critical illness myopathy (CIM). CIM is associated with increased mortality and significant consequences for recovery and the ability to return to normal daily life. Up to date, there are no studies investigating the mid- or long-term course of the novel COVID-19 disease. The present study therefore aims to evaluate the clinical outcome of patients with ARDS due to SARS-CoV-2 with special attention to the development of CIM and its underlying causes. To provide the possibility of early diagnosis of CIM, critically ill patients will be regularly screened for muscle membrane alterations using (Muscle velocity recovery cycles) MRVC measurements. The primary endpoint is the incidence of CIM in patients with ARDS due to SARS-CoV-2, diagnosed according to the current diagnostic criteria.
Description: Short Form (36) Health Survey (SF-36)
Measure: Short Form (36) Health Survey (SF-36) Time: 3 monthsDescription: Mortality
Measure: Mortality Time: 90 daysDescription: Modified Rankin Scale (mRS); (0=no Symptoms at all, 6=dead)
Measure: Modified Rankin Scale (mRS) Time: 90 daysDescription: Duration of mechanical ventilation in days
Measure: Duration of mechanical ventilation in days Time: 3 monthsDescription: Barthel Index (80-100= patient should be able to live independently, <20=total dependence)
Measure: Barthel Index Time: 3 monthsDescription: Beck's Depression Inventory II (BDI-II)
Measure: Beck's Depression Inventory II (BDI-II) Time: 3 monthsDescription: Essener Questionnaire for Coping with a Disease (EFK); (0=no burden of disease, 180-strong burden of disease)
Measure: Essener Questionnaire for Coping with a Disease (EFK) Time: 3 monthsDescription: Number of patients with Critical Illness Myopathy
Measure: Number of patients with Critical Illness Myopathy Time: day 10