Name (Synonyms) | Correlation | |
---|---|---|
drug2665 | Vitamin Super B-Complex Wiki | 0.50 |
drug565 | Chloroquine diphosphate Wiki | 0.35 |
drug1708 | Other drugs Wiki | 0.35 |
drug2202 | Sars-Cov-2 serology Wiki | 0.35 |
drug2004 | RO6953958 Wiki | 0.35 |
drug1578 | Natural Honey Wiki | 0.35 |
drug560 | Chloroquine Wiki | 0.25 |
drug1592 | Niclosamide Wiki | 0.25 |
drug601 | Colchicine Wiki | 0.25 |
drug3005 | standard care Wiki | 0.20 |
drug2300 | Standard Care Wiki | 0.18 |
drug1270 | Ivermectin Wiki | 0.17 |
drug1822 | Placebo Wiki | 0.14 |
drug1484 | Methylprednisolone Wiki | 0.11 |
drug923 | Favipiravir Wiki | 0.09 |
drug1853 | Placebo oral tablet Wiki | 0.07 |
drug262 | Azithromycin Wiki | 0.06 |
Name (Synonyms) | Correlation | |
---|---|---|
D002658 | Developmental Disabilities NIH | 0.35 |
D065886 | Neurodevelopmental Disorders NIH | 0.25 |
D002659 | Child Development Disorders, Pervasive NIH | 0.20 |
D001321 | Autistic Disorder NIH | 0.18 |
D000067877 | Autism Spectrum Disorder NIH | 0.14 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.09 |
D018352 | Coronavirus Infections NIH | 0.09 |
D013577 | Syndrome NIH | 0.08 |
D001523 | Mental Disorders NIH | 0.08 |
D004194 | Disease NIH | 0.06 |
D011014 | Pneumonia NIH | 0.06 |
D011024 | Pneumonia, Viral NIH | 0.04 |
D014777 | Virus Diseases NIH | 0.04 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.03 |
D007239 | Infection NIH | 0.02 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0000717 | Autism HPO | 0.18 |
HP:0000729 | Autistic behavior HPO | 0.14 |
HP:0002090 | Pneumonia HPO | 0.06 |
There are 8 clinical trials
Trial to evaluate the efficacy and safety of NTZ for post-exposure prophylaxis of COVID-19 and other VRIs in elderly LTCF residents.
Description: The proportion of subjects with symptomatic laboratory-confirmed COVID-19 identified after start of treatment and before the end of the 6-week treatment period.
Measure: Symptomatic laboratory-confirmed COVID-19 Time: up to 6 weeksDescription: The proportion of subjects with symptomatic laboratory-confirmed VRI identified after the start of treatment and before the end of the 6-week treatment period.
Measure: Symptomatic laboratory-confirmed VRI Time: up to 6 weeksCOVID 19 treatment using Chloroquine with or without Azithromycin, Faviprevir, Nitazoxanide, Ivermectin.
Description: the estimated number of patients with decreased viral load
Measure: Number of patients with decreased viral load Time: 6 monthsTrial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Post Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses (VRI) in Healthcare Workers
Azithromycin has been shown to have a clinical efficacy against severe acute respiratory syndrome coronavirus 2; ivermectin has also demonstrated a remarkable experimental efficacy with a potential to be used for Coronavirus disease 2019.
Description: the number of patients with virological cure
Measure: Number of patients with virological cure Time: 6 monthsThis is a proof of concept study to evaluate the efficacy of nitazoxanide (600 mg TID) to treat hospitalized patients with non-critical COVID-19.
Description: PCR will be done to evaluate the change in viral load
Measure: Viral load Time: day 1, 4, 7, 14 and 21Description: Time to wean off oxygen supplementation
Measure: Evolution of acute respiratory syndrome Time: 21 daysDescription: WHO Ordinal Scale for Clinical Improvement that measures illness severity over time (0=uninfected; ambulatory, no limitation of activities=1; ambulatory, limitation of activities=2, hospitalized no oxygen therapy=3; hospitalized oxygen by mask or nasal prongs=4; hospitalized non invasive ventilation or high-flow oxygen=5; hospitalized intubation or mechanical ventilation=6; hospitalized ventilation + additional organ support=7; death=8)
Measure: Change in Clinical Condition Time: 21 daysDescription: Time to be discharged from hospital
Measure: Hospital discharge Time: 21 daysDescription: Evaluation of change in acute respiratory syndrome
Measure: Rate of mortality within 21-days Time: 21 daysDescription: Evaluation of change in acute respiratory syndrome
Measure: Need of mechanical ventilation Time: 21 daysThe primary objective of this study is to evaluate the efficacy of the drug nitazoxanide 600 mg, administered three times a day, in relation to placebo in preventing the development of COVID-19 in subjects from vulnerable communities that had direct contact with patients diagnosed with the disease.
Description: PCR will be done to evaluate infection
Measure: The proportion of subjects with laboratory-confirmed COVID-19 identified after start of treatment and before the end of the study Time: 28 daysDescription: Number of participants with treatment-related adverse events
Measure: Incidence of Treatment-Emergent Adverse Events Time: 28 daysDescription: Symptomatic PCR positive subjects
Measure: The proportion of subjects with symptomatic laboratory-confirmed COVID-19 identified after start of treatment and before the end of the study Time: 28 daysDescription: Asymptomatic PCR will be done to evaluate infection
Measure: The proportion of subjects with asymptomatic laboratory-confirmed COVID identified after the start of treatment and before the end of the study Time: 28 daysDescription: Subject adherence to treatment will be assessed through study diary record
Measure: Treatment adherence Time: 7 daysDescription: Proportion of patients with severe condition
Measure: Disease complication Time: 28 daysDescription: Proportion of patient that needed undergo an unscheduled visit
Measure: Incidence of subjects that underwent unscheduled visit Time: 28 daysThe aim is to demonstrate a decrease in complications among ambulatory patients who are diagnosed with mild COVID-19 by treating them with nitazoxanide for 7 to 14 days on top of standard care compared to patients who receive standard care and placebo only.
Description: Symptoms will be assessed using a 5 point scale (1- excellent, 2- good, 3- fair, 4 - poor 5 - very poor).
Measure: Change in signs and symptoms scale Time: 21 daysDescription: Number of participants with treatment-related adverse events
Measure: Incidence of Treatment-Emergent Adverse Events Time: 21 daysDescription: Change in clinical condition - WHO Ordinal Scale for Clinical Improvement that measures illness severity over time (0=uninfected; ambulatory, no limitation of activities=1; ambulatory, limitation of activities=2, hospitalized no oxygen therapy=3; hospitalized oxygen by mask or nasal prongs=4; hospitalized non invasive ventilation or high-flow oxygen=5; hospitalized intubation or mechanical ventilation=6; hospitalized ventilation + additional organ support=7; death=8)
Measure: The proportion of subjects hospitalized after start of treatment and before the end of the study Time: 21 daysDescription: Change in clinical condition - WHO Ordinal Scale for Clinical Improvement that measures illness severity over time (0=uninfected; ambulatory, no limitation of activities=1; ambulatory, limitation of activities=2, hospitalized no oxygen therapy=3; hospitalized oxygen by mask or nasal prongs=4; hospitalized non invasive ventilation or high-flow oxygen=5; hospitalized intubation or mechanical ventilation=6; hospitalized ventilation + additional organ support=7; death=8)
Measure: The proportion of subjects that need mechanical ventilation after start of treatment and before the end of the study Time: 21 daysDescription: Time required (days) to full symptom recovery
Measure: Duration of symptoms Time: 21 daysDescription: Evaluation of change in acute respiratory syndrome
Measure: Rate of mortality within 21-days Time: 21 daysEvaluation of the efficacy and safety of NTX in adult patients (≥18 years and <60 years), with SARS-CoV-2 infection with mild symptoms of COVID-19, compared to a placebo control arm. 135 patients will be randomized to either Nitazoxanide (n=90) or placebo (n=45) (2:1). Simple blind design. Primary endpoint: eradication of virus from patients' respiratory tract secretions by the 7th day of treatment.
Description: Erradication will be considered a reduction of the viral load on day 7 greater than 35% with respect to placebo. Extraction of genomic material will be performed using a QIAgen mini kit (QIAmp viral RNA) validated by the CDC (United States Center for Disease Control and Prevention (https://www.fda.gov/media/134922/download) (CDC-006-00019) Viral load will be quantified with the following detection kits: Commercial Kit: PCR-EUA-CDC-nCoV-IFU. Commercial KIT SENTINEL - STAT-NAT Covid 19B (Berlín). Rational: In mild cases of COVID-19, 50% of the patients eradicated the virus within a period of 3 weeks, 25% eradicated the virus before the 13th day, 75% during the first month and the rest were " late eradicators." This latter subgroup of patients has been associated with severe cases of COVID-19 disease.
Measure: Eradication of SARS COV-2 from patients' respiratory tract secretions by treatment day 7th. Time: 7 dayDescription: Consequently, in mild cases, viral eradication will likely occur more frequently during the first to second week of COVID-19 disease; less than 15% could eradicate the virus during the first week of symptom onset. From an epidemiological point of view, increasing the viral eradication rate from less than 15% to more than 35% during the first two weeks of treatment would be clinically relevant.(seven), 14 (fourteen) and 35 (thirty-five) after starting treatment compared to the baseline measurement.
Measure: Comparative decrease of the viral load Time: 3 - 35 daysDescription: Clinical improvement according to the WHO COVID-19 ordinal scale. Minimun 0 (zero), (best), maximum 8 (eight) (worst)
Measure: Clinical improvement Time: 1 - 35 daysDescription: Percentage of pneumonia patients meeting severity criteria.
Measure: Pneumonia patients meeting severity criteria. Time: 1 - 35 daysDescription: Number of days with fever (axillary temperature higher than 37.5°C).
Measure: Number of days with fever Time: 1 - 35 daysDescription: Percentage of patients requiring mechanical ventilation through orotracheal intubation (OT) and/or ICU hospitalization.
Measure: Patients requiring mechanical ventilation Time: 1 - 35 daysDescription: Mortality rate.
Measure: Mortality rate. Time: 1- 35 daysDescription: Lymphocyte recovery (absolute lymphocyte count > 1000 / mm3).
Measure: Lymphocyte recovery Time: 7 dayDescription: Days of ICU hospitalization.
Measure: ICU hospitalization. Time: 1 - 35 daysDescription: Oxygen saturation (SpO2) > 92% (at ambient FiO2).
Measure: Oxygen saturation Time: 1 - 35 daysDescription: Days of hospitalization
Measure: Days of hospitalization Time: 1 - 35 daysDescription: Respiratory rate per minute (in afebrile state conditions).
Measure: Respiratory rate Time: 1 - 35 days