There is one clinical trial.
A randomized controlled pilot study on the safety & efficacy of imatinib for the treatment of patient with moderate to severe SARS-COV-2 induced pneumonia.
Description: Proportion of patients with COVID-19 pneumonia progressed to critical illness in need for invasive mechanical ventilation.
Measure: Primary endpoint: Disease Progression Time: 30 DaysDescription: Improvement of Hypoxic index( PaO2 / FiO2) calculated daily
Measure: Improvement in Hypoxic Index Time: From inclusion to 30 days follow upDescription: Hospital Length of stay
Measure: Hospital Length of Stay Time: From inclusion to 30 days follow upDescription: Days on mechanical ventilation for patients needing intubation & invasive mechanical ventilation
Measure: Days on invasive mechanical ventilation Time: From inclusion to 30 days follow upDescription: Difference in the median levels of serum IL-6, serum ferritin, CRP at the end of the follow up period between all groups
Measure: Inflammatory Markers Time: From inclusion to 30 daysDescription: Rate of viral clearance as monitored by SARS-COV-2 PCR
Measure: Viral clearance Time: From inclusion to 30 daysDescription: Difference in the overall evaluation of pulmonary infiltrative (improving / deteriorating) as assessed by imaging (Chest X-ray or Non-contrast pulmonary CT)
Measure: Radiological assessment Time: From inclusion to 30 daysDescription: Rate of serious adverse events (SAEs)
Measure: Safety of Imatinib Time: From inclusion to 60 days