Name (Synonyms) | Correlation | |
---|---|---|
drug960 | Follow up Wiki | 0.71 |
drug603 | Colchicine Tablets Wiki | 0.58 |
There is one clinical trial.
Participants will be randomized in a 1:1 ratio to receive Colchicine plus current care per UCLA treating physicians versus current care per UCLA treating physicians alone (control arm). Importantly, this adaptive trial design allows for patients in either study arm to receive other investigational drugs for COVID-19 as new science emerges.
Description: Number of participants experiencing any of the following: All-cause mortality, need for mechanical ventilation, or need for mechanical circulatory support (MCS)
Measure: Composite of all-cause mortality, need for mechanical ventilation, or need for mechanical circulatory support (MCS) Time: 90 DaysDescription: Change from initial troponin level to maximum level of troponin among measures taken during hospitalization and at 30 days
Measure: Delta (peak minus baseline) troponin level Time: Baseline (Day 1), Day 30, Days 3 and 7 if hospitalizedDescription: Change from baseline BNP level (Day 1) to maximum level of BNP among measures taken during hospitalization and at 30 days
Measure: Delta (baseline to peak) brain natriuretic peptide (BNP) level Time: Baseline (Day 1), Day 30, Days 3 and 7 if hospitalizedDescription: Number of participants experiencing LVEF of < 50% on echocardiogram with failure to show an improvement of ≥ 5% at 30 days
Measure: Change in left ventricular ejection fraction (LVEF) on echocardiography Time: Baseline, Day 30Description: D-Dimer is a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis, so named because it contains two D fragments of the fibrin protein joined by a cross-link
Measure: Delta (peak minus baseline) D-Dimer inflammatory biomarker level Time: Baseline (Day 1), Day 30, Days 3 and 7 if hospitalizedDescription: Number of participants released and re-admitted to the hospital within 90 days of enrollment
Measure: Re-hospitalization at 90 days Time: 90 days