Correlated Drug Terms (1)

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	Name (Synonyms)	Correlation
drug2736	alpha one antitrypsin inhalation Wiki	1.00

Correlated MeSH Terms (2)

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	Name (Synonyms)	Correlation
D045169	Severe Acute Respiratory Syndrome NIH	0.05
D018352	Coronavirus Infections NIH	0.04

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: The sensitivity and specificity of serological tests (positive or negative) compared to molecular detection of the virus by PCR

Measure: The positivity (Yes/No) of the serological test.

Time: Day 0

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Description: The sensitivity and specificity of serological tests (positive or negative) compared to molecular detection of the virus by PCR

Measure: The positivity (Yes/No) of the serological test.

Time: Day 3

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Description: The sensitivity and specificity of serological tests (positive or negative) compared to molecular detection of the virus by PCR

Measure: The positivity (Yes/No) of the serological test.

Time: Day 7

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Description: The sensitivity and specificity of serological tests (positive or negative) compared to molecular detection of the virus by PCR

Measure: The positivity (Yes/No) of the serological test.

Time: Day 14

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Description: The sensitivity and specificity of serological tests (positive or negative) compared to molecular detection of the virus by PCR

Measure: The positivity (Yes/No) of the serological test.

Time: Day 21

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Description: The sensitivity and specificity of serological tests (positive or negative) compared to molecular detection of the virus by PCR

Measure: The positivity (Yes/No) of the serological test.

Time: Day 28

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Description: The sensitivity and specificity of serological tests (positive or negative) compared to molecular detection of the virus by PCR

Measure: The positivity (Yes/No) of the serological test.

Time: Day 35

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Description: The sensitivity and specificity of serological tests (positive or negative) compared to molecular detection of the virus by PCR

Measure: The positivity (Yes/No) of the serological test.

Time: Day 42

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Secondary Outcomes

Measure: Measurement of IgM and IgG antibody titer at each sampling of weekly and monthly visits of covid-19+ patients and implementation of the kinetics of mean appearance.

Time: Day 42

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Measure: - Among the symptomatic PCR negative patients recruited into the study at the first visit, the measurement of the IgM antibody and IgG titer will be performed in serum at D28, and the positive results will then constitute the false-negative PCR results.

Time: Day 28

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Measure: - Measurement of IgM and IgG antibody titer at each sampling of late patient visits.

Time: Day 42

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Measure: - The neutralizing capacity of the antibodies will be determined by in vitro serum neutralization tests on seropositive serum. A group of 50 patients made up of seropositive and asymptomatic caregivers at the time of infection will represent this group.

Time: Day 42

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