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drug1086 | Hydroxychloroquine Wiki | 0.10 |
drug1822 | Placebo Wiki | 0.06 |
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There is one clinical trial.
The aim of this study is to determine if Povidone iodine (PVP-I) rinses and throat gargles or a PVP-I gel forming nasal spray compared to a placebo (a treatment that has no physical effect to a person) is an effective treatment for patients diagnosed with COVID-19. These patients have been diagnosed with mild/moderate COVID-19 symptoms and sent home for self-isolation. Patients will be instructed to take either of the two treatments or placebo twice daily for two weeks and have follow up visits 2 and 4 weeks after. The participants will also complete study related procedures such as saliva sample collection, and two questionnaires throughout the study period. The investigators hypothesize that COVID 19 positive participants who use either of the Povidone - Iodine treatment will have a reduction in their viral load, develop a negative oral mucosa sample and improve their clinical symptoms.
Description: A saliva sample will be analyzed to monitor the duration of positivity and when test becomes negative for SARS-CoV-2.
Measure: Change in SARS-CoV-2 positivity in the saliva Time: A saliva sample will be taken every 2 days for 2 weeks, and again at 4 and 6 weeksDescription: Quantify the amount of SAR-CoV-2 viral load present in the saliva.
Measure: Change in the SAR-CoV-2 viral load in the saliva Time: A saliva sample will be taken every 2 days for 2 weeks, and again at 4 and 6 weeksDescription: This is a 44 question, quality of life survey designed to measure different aspects affected by the common cold.
Measure: Change in Wisconsin Upper Respiratory Symptom Survey (WURSS-44) Time: daily for 2 weeks, 4 weeks, and 6 weeksDescription: That includes 22 questions about symptoms and social/emotional consequences of your nasal disorder.
Measure: Change Sino nasal Outcome Test (SNOT-22) Time: baseline, 2 weeks, 4 weeks, 6 weeksDescription: We will record and worsening of clinical condition such as, need for hospitalization/oxygen support.
Measure: Change in clinical condition Time: daily for 2 weeks, 4 weeks, and 6 weeks