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computerized cognitive training (CCT)Wiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug599 Cognitive behavioral therapy (CBT) Wiki 1.00
drug372 Blood collection on their first consultation and 10 to 14 days later Wiki 1.00
drug371 Blood collection on admission and longitudinally Wiki 1.00

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D001008 Anxiety Disorders NIH 0.17

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Neurally Targeted Cognitive Training to Augment Cognitive Behavioral Therapy (CBT) Outcomes in Pediatric Anxiety

This study will assign eighteen participants with anxiety to cognitive behavioral therapy (CBT) with computerized cognitive training (CCT). In addition, the study will have a control group and enroll thirty-six age- and gender-matched anxious children assigned to CBT. The hypothesis of this trial is that CCT with CBT will further increase task control network (TCN) activation and connectivity. Both groups will have one CBT therapy session each week for 12 weeks. However, for participants in the CCT arm plus CBT they will also receive up to 4 weeks of at home CCT to complete during the two weeks prior to the first CBT session and during the two weeks after the first CBT session. CCT is to be done at home for approximately 30 minutes per day, 5 days per week. Additionally, participants in the CCT arm plus CBT will receive CCT for 30 minutes just prior to CBT sessions 4-12. Each group will also have pre and post therapy functional magnetic resonance imaging (fMRI) and be asked to complete anxiety severity interviews and questionnaires throughout the study as well as after the treatment. Update as of 4/7/2020: Enrollment and in-person-only interactions/interventions are temporarily paused due to COVID-19 and are expected to resume in the future. This is not a suspension of IRB approval.

NCT04157296 Anxiety Disorders Behavioral: Cognitive behavioral therapy (CBT) Behavioral: computerized cognitive training (CCT)
MeSH:Anxiety Disorders

Primary Outcomes

Description: Pre- to post-CBT changes in brain activation and function connectivity in the task-control network including fronto-parietal and cingulo-opercular regions mediating cognitive control. Functional activation and connectivity of these brain regions are assessed using a conflict interference computer task performed during MRI scanning.

Measure: Change in Brain activation and connectivity in the task-control network (TCN)

Time: Baseline, 12 weeks (after therapy)

Secondary Outcomes

Description: This is a 50 question interview-based tool used to assess for the presence and severity of anxiety symptoms in children and adolescents utilizing parental and youth input to guide clinician ratings. The total scores on this scale range from 0 to 30, with scores above 13 indicating clinically meaningful anxiety.

Measure: Change in Pediatric Anxiety Rating Score (PARS)

Time: Baseline, 12 weeks (after therapy)

Description: Pre- to post-CBT changes in the behavioral performance in a conflict interference task, as well as, composite score from tasks included in the NIH toolbox

Measure: Change in behavioral performance on the conflict interference task and tasks testing cognitive control capacity included in the NIH Toolbox.

Time: Baseline, 12 weeks (after therapy)


No related HPO nodes (Using clinical trials)