CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Standard of care treatmentWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (5)


Name (Synonyms) Correlation
drug1099 Hydroxychloroquine Only Product in Oral Dose Form Wiki 0.71
drug1286 JNJ-53718678 Wiki 0.71
drug1094 Hydroxychloroquine , Sofosbuvir, daclatasvir Wiki 0.71
drug923 Favipiravir Wiki 0.17
drug1822 Placebo Wiki 0.04

Correlated MeSH Terms (6)


Name (Synonyms) Correlation
D018357 Respiratory Syncytial Virus Infections NIH 0.29
D003141 Communicable Diseases NIH 0.12
D014777 Virus Diseases NIH 0.09
D007239 Infection NIH 0.08
D045169 Severe Acute Respiratory Syndrome NIH 0.04
D018352 Coronavirus Infections NIH 0.03

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There are 2 clinical trials

Clinical Trials


1 A Phase 2 Randomized, Double Blinded, Placebo Controlled Study of Oral Favipiravir Compared to Standard Supportive Care in Subjects With Mild or Asymptomatic COVID-19

The objective of this study is to evaluate the efficacy of oral favipiravir plus standard of care treatment (SOC) compared with placebo plus SOC in reducing the duration of shedding of SARS-CoV2 virus in patients with mild or asymptomatic COVID-19.

NCT04346628 Sars-CoV2 COVID-19 Drug: Favipiravir Drug: Placebo Other: Standard of care treatment

Primary Outcomes

Description: Time in days from randomization to the first two negative results of nasal and/or oropharyngeal swab.

Measure: Time until cessation of oral shedding of SARS-CoV-2 virus

Time: Up to 28 days

Secondary Outcomes

Description: Viral load will be assessed as the TCID50 (Median Tissue Culture Infectious Dose) over time.

Measure: Sars-CoV-2 viral load

Time: Up to 28 days

Description: Clinical worsening will be determined by clinician assessment.

Measure: Count of participants with clinical worsening of COVID-19 disease

Time: Up to 28 days

Measure: Count of participants with development of SARS-CoV-2 antibodies

Time: Up to 28 days

Measure: Time until cessation of symptoms

Time: Up to 28 days

Description: This outcome will be assessed in patient who are asymptomatic of COVID-19 infection at the time of enrollment

Measure: Count of participant with absence of development of any symptoms

Time: Up to 28 days

Description: Cmax is a pharmacokinetic parameter that measures the maximum concentration of drug in plasma.

Measure: Cmax of favipiravir

Time: Days 1 and 10 (samples taken 30 minutes prior to and 1 hour following favipiravir administration)

Description: Cmin is a pharmacokinetic parameter that measures the minimum concentration of drug in plasma.

Measure: Cmin of favipiravir

Time: Days 1 and 10 (samples taken 30 minutes prior to and 1 hour following favipiravir administration)

2 Efficacy and Safety of Anti-hepatitis C Drugs in the Treatment of COVID-19

COVID 19 which started from a zoonotic transmission related to crowded markets was confirmed to have a high potential for transmission to close contacts on 20 January 2020 by the National Health Commission of China and it was announced as a pandemic by the WHO on 11 March 2020. There is currently no clinically proven specific antiviral agent available for SARS-CoV-2 infection. Supportive treatment, including oxygen therapy, conservation fluid management, and broad-spectrum antibiotics to cover secondary bacterial infection, remains the most important management strategy. Interestingly, sofosbuvir has recently been proposed as an antiviral for the SARS-CoV-2 based on the similarity between the replication mechanisms of the HCV and the coronaviruses. Aim of the study is to assess the safety and efficacy of of the addition of HCV treatment to the standard regimen for the treatment of patients who are candidates to receive Hydroxy Chloroquine according to Egyptian MOHP protocol

NCT04443725 COVID-19 Drug: Hydroxychloroquine , Sofosbuvir, daclatasvir Drug: Standard of care treatment

Primary Outcomes

Description: virological cure using the triple therapy as compared to mono hydroxychloroquine treatment..

Measure: Virological cure

Time: 28 days


No related HPO nodes (Using clinical trials)