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prone positionWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)


Name (Synonyms) Correlation
drug2787 convalescent plasma Wiki 0.35

Correlated MeSH Terms (5)


Name (Synonyms) Correlation
D012128 Respiratory Distress Syndrome, Adult NIH 0.12
D012127 Respiratory Distress Syndrome, Newborn NIH 0.07
D011014 Pneumonia NIH 0.04
D045169 Severe Acute Respiratory Syndrome NIH 0.04
D018352 Coronavirus Infections NIH 0.03

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0002090 Pneumonia HPO 0.04

There are 2 clinical trials

Clinical Trials


1 Impact of Prone Position in Patients Under Spontaneous Breathing on Intubation or Non-invasive Ventilation or Death Incidence During COVID-19 Acute Respiratory Distress

The SARS-Cov2 viral pandemic is responsible for a new infectious disease called COVID-19 (CoronaVIrus Disease), is a major health problem. Respiratory complications occur in 15 to 40%, the most serious is acute respiratory distress syndrome (ARDS). The management of COVID-19 is essentially symptomatic with respiratory oxygen supplementation in mild forms to invasive mechanical ventilation in the most severe forms. Prone position (PP) reduced mortality in patients with ARDS in intensive care. Ding et al showed that PP and high flow oxygenation reduced the intubation in patients with moderate to severe ARDS. The investigators hypothesize that the use of PP in spontaneously ventilation patients under oxygen standard could decrease incidence of intubation or non-invasive ventilation or death compared to conventional positioning management in medical departments.

NCT04363463 COVID19 Oxygen Therapy Prone Position Spontaneous Ventilation Respiratory Distress Syndrome Other: prone position
MeSH:Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome, Adult

Primary Outcomes

Description: To show that PP in spontaneously ventilation patients could reduce the risk of acquiring the following event (composite endpoint): Endotracheal intubation Or non-invasive ventilation (NIV) with two pressure levels And/or death

Measure: Percent age of patients who will have endotracheal intubation or non-invasive ventilation at two pressure levels and/or die, in each of the 2 randomization groups.

Time: Day 28

Secondary Outcomes

Description: Show that the use of prone position improves the WHO ordinal scale score by 2 points faster (after randomization)

Measure: Duration in days for the change of 2 points on the WHO ordinal scale

Time: Day 28

Description: Show that prone position with spontaneous ventilation reduces the need for endotracheal intubation and invasive mechanical ventilation

Measure: Rate (%) of intubation and invasive ventilation in the 2 randomization groups.

Time: Day 28

Description: Show that prone position with spontaneous ventilation reduces the use of non-invasive ventilation at two pressure levels

Measure: Rate (%) of non-invasive ventilation at two pressure levels in the 2 randomization groups

Time: Day 28

Description: Show that prone position in spontaneous ventilation reduces the time under oxygen therapy.

Measure: Duration of oxygen therapy in the 2 randomization groups.

Time: Day 28

Description: Show that prone position reduces the length of hospitalization.

Measure: Duration of hospitalization in the 2 randomization groups.

Time: Day 28

Description: Compare the hospital mortality of the 2 groups

Measure: Hospital mortality and mortality at D28 in the 2 randomization groups

Time: Day 28

Description: Compare the incidence of the need for resuscitation transfer between the two groups.

Measure: Rate (%) of need for transfer to intensive care unit

Time: Day 28

Description: Compare the impact of the use of non-invasive ventilation and intubation on the entire hospital stay when the hospital stay is longer than 28 days between the two groups.

Measure: Rate (%) of use of non-invasive ventilation at two pressure levels, intubation throughout the entire stay when the stay is longer than 28 days.

Time: 1 year

2 The Effect of Early Prone Position on Prognosis in Acute Respiratory Failure Due to Coronavirus Disease 2019 Pneumonia

the purpose of this study to evaluate the effect of early awake PP (prone position)application on oxygenation and intubation requirement in patients with acute respiratory failure due to coronavirus disease 2019 pneumonia.

NCT04427969 Coronavirus Infection Acute Respiratory Failure Behavioral: prone position
MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Pneumonia Respiratory Insufficiency Respiratory Distress Syndrome, Adult
HPO:Pneumonia

Primary Outcomes

Description: the duration of icu stay day

Measure: intensive care unit stay

Time: up to 28 days

Description: mortality percent

Measure: short term mortality

Time: up to 28 days

Secondary Outcomes

Description: partial oxygen pressure: mmhg , partial carbondiocsit pressure mmhg

Measure: blood gases

Time: up to 24 hours


Related HPO nodes (Using clinical trials)