CovidResearchTrials by Shray Alag

CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)

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Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


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Name (Synonyms) Correlation

Correlated MeSH Terms (1)

Name (Synonyms) Correlation
D053120 Respiratory Aspiration NIH 0.38

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Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials

1 Impact of Neck Inspiratory Muscle Activation During Sleep in ICU Patients After a COVID 19 ARDS

Most patients in intensive care units (ICUs) experience severe sleep disruption. Sleep disruption and sleep alteration may have an influence on the ability to breathe spontaneously. But, the cause of altered sleep remains unknown. Previous studies have shown that decreasing nocturnal respiratory muscle activity through mechanical ventilation might improve sleep quality. Nocturnal respiratory muscle activity may be one of the potential factor which contribute to alter sleep in the ICU. Therefore, the aim of this study is to analyse the presence of NIM activation during the night and it's consequence in an ICU population with the same pathology (COVID 19 ARDS).

NCT04371029 ARDS COVID-19 Other: PSG
MeSH:Respiratory Aspiration

Primary Outcomes

Description: Comparison between patients with NIM activation during the night and patients without NIM activation during the night, in patients COVID 19 ARDS with altered spleep. A Polysomnography (PSG) will be performed the night before extubation.

Measure: Proportion of patients with altered spleep

Time: At day 10 after inclusion

Secondary Outcomes

Description: Thanks to a PSG the night befor discharge, the seep architecture will be estimated.

Measure: Sleep architecture at hospital discharge

Time: At day 28 after inclusion

Description: Thanks to actimetry measure during hospitalization in the post ICU ward.

Measure: Sleep monitoring during hospital stay after ICU discharge

Time: At day 18 after ICU discharge

Description: Sleep quality will be evaluate by the Pittsburgh sleep quality index. The 7 components of the score add up for give an overall score ranging from 0 to 21 points, 0 meaning that there is no difficulty, and 21 indicating on the contrary major difficulties.

Measure: Sleep quality

Time: 3 months after hospiotal discharge

Description: Thanks to a PSG at 3 months, the seep architecture will be estimated.

Measure: Sleep architecture at month-3

Time: 3 months after hospital discharge

Description: all cost will be estimated during ICU hospitalization.

Measure: Cost of ICU hospitalization

Time: From inclusion to ICU discharge, up to 10 days after inclusion

No related HPO nodes (Using clinical trials)