Name (Synonyms) | Correlation | |
---|---|---|
drug2812 | evaluation of skin microvascular flow and reactivity Wiki | 1.00 |
Name (Synonyms) | Correlation | |
---|---|---|
D000073436 | Microvascular Rarefaction NIH | 1.00 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.05 |
D018352 | Coronavirus Infections NIH | 0.04 |
Name (Synonyms) | Correlation |
---|
There is one clinical trial.
In December 2019, a new type of pneumonia, COVID-2019 outbroke in Wuhan ,China, and currently the infected has been reported in more than at least 75 countries. Patients with severe COVID-19 have rapid disease progression and high mortality rate. This may attribute to the excessive immune response caused by cytokine storm. Strategies based on anti-virus drugs and treatments against symptoms have now been employed. However, these managements can't effectively treat the lethal lung injury and uncontrolled immune responses, especially in the elderly with severe COVID-19. Traditional Chinese Medicine (TCM), which treats the disease from anther perspective, has achieved satisfactory results. National Health Commission of China released a series of policies to enhance the administration of TCM prescriptions. This study is aimed to evaluate the efficacy and safety of Traditional Chinese Medicine as an adjuvant treatment for severe COVID-19.
Description: The pneumonia severity index is a clinical tool helping in the risk stratification of patients with community-acquired pneumonia. It ranges from 0-395 scores and a higher score indicates higher death risk.
Measure: The pneumonia severity index scores Time: First treatment date up to 3 monthsDescription: Changes in leukocyte, neutral, lymphocyte counts and absolute lymphocyte count from baseline
Measure: Blood immune cell count Time: Baseline, 7 and/ or 14 daysDescription: Changes in blood interleukin-6, c-reactive protein,SS-A/Ro antibodies and serum ferritin from baseline.
Measure: Serum inflammatory markers Time: Baseline, 7 and/ or 14 daysDescription: Changes in erythrocyte sedimentation rate from baseline.
Measure: Erythrocyte sedimentation rate Time: Baseline, 7 and/ or 14 daysDescription: Changes in platelets and D-dimers from baseline.
Measure: Platelet and D-dimer changes Time: Baseline, 7 and/ or 14 daysDescription: Changes in serum creatinine from baseline.
Measure: Creatinine changes Time: Baseline, 7 and/ or 14 daysDescription: Changes in serum muscle enzymes from baseline, including alanine aminotransferase , AST, creatine kinase, LDH.
Measure: Muscle enzymes changes Time: Baseline, 7 and/ or 14 daysDescription: Dosing time and amounts of antibiotics;the categories of the antibiotics
Measure: Usage of antibiotics Time: First treatment date up to 3 monthsDescription: Dosing time and amounts of glucocorticoids
Measure: Usage of glucocorticoids Time: First treatment date up to 3 months